Adducin 1 (ADD1)

ADDA; Alpha-Adducin; Erythrocyte adducin subunit alpha

SPN	U565
HGNC	243
MGI	87918
PubMed	24379415
RGD	2041
UniProt	P35611
Wiki	ADD1

Alpha-adducin is a protein encoded by the ADD1 gene.Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2 )/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Reference

"Primary structure and domain organization of human alpha and beta adducin."
J. Cell Biol. 115:665-675(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning and mapping of the alpha-adducin gene close to D4S95 and assessment of its relationship to Huntington disease."
Hum. Mol. Genet. 1:669-675(1992) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the human alpha-adducin gene and its alternately spliced isoforms."
Genomics 25:93-99(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of the alpha-adducin gene from the Huntington's disease candidate region of chromosome 4 by exon amplification."
Nat. Genet. 2:223-227(1992) [PubMed] [Europe PMC] [Abstract]

"Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C."
J. Biol. Chem. 271:25157-25166(1996) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility."
J. Cell Biol. 145:347-361(1999) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Human alpha-adducin gene, blood pressure, and sodium metabolism."
Hypertension 32:138-143(1998) [PubMed] [Europe PMC] [Abstract]

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]