Allograft Inflammatory Factor 1 (AIF1)

IBA1; IRT1; Daintain; Protein G1; Ionized calcium-binding adapter molecule 1

SPN	U557
HGNC	352
MGI	1343098
PubMed	17522098
RGD	61924
UniProt	P55008
Wiki	AIF1

Allograft inflammatory factor 1 is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma.

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Reference

"Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins."
Hum. Mol. Genet. 3:793-799(1994) [PubMed] [Europe PMC] [Abstract]

"Cloning and genomic characterization of LST1: a new gene in the human TNF region."
Immunogenetics 42:315-322(1995) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries."
Biochem. Biophys. Res. Commun. 228:29-37(1996) [PubMed] [Europe PMC] [Abstract]

"Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts."
Transplantation 61:1387-1392(1996) [PubMed] [Europe PMC] [Abstract]

"Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing."
Genomics 45:591-600(1997) [PubMed] [Europe PMC] [Abstract]

"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF."
Arterioscler. Thromb. Vasc. Biol. 24:1217-1222(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies."
Am. J. Pathol. 167:619-626(2005) [PubMed] [Europe PMC] [Abstract]

"Structural and functional characterization of human Iba proteins."
FEBS J. 275:4627-4640(2008) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding."
J. Mol. Biol. 364:449-457(2006) [PubMed] [Europe PMC] [Abstract]

"NMR structure of the human allograft inflammatory factor 1."
Submitted (FEB-2009) to the PDB data bank