Asporin (ASPN)
PLAP1; SLRR1C; Periodontal ligament-associated protein 1
Asporin, ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin.Higher levels in osteoarthritic articular cartilage, aorta, uterus. Moderate expression in small intestine, heart, liver, bladder, ovary, stomach, and in the adrenal, thyroid, and mammary glands. Low expression in trachea, bone marrow, and lung.
Variation in the poly-Asp region of ASPN is associated with osteoarthritis susceptibility type 3 (OS3) ; also known as osteoarthritis of knee/hip. Osteoarthritis is a common disease that produces joint pain and stiffness together with radiologic evidence of progressive degeneration of joint cartilage.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU524Hu01 | Recombinant Asporin (ASPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU524Hu01 | Monoclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IP. |
| PAU524Hu01 | Polyclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU524Hu01 | CLIA Kit for Asporin (ASPN) | CLIA assay for Antigen Detection |
| ELU524Hu01 | ELISA Kit for Asporin (ASPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU524Mu01 | Recombinant Asporin (ASPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU524Mu01 | Monoclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IP. |
| PAU524Mu01 | Polyclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU524Mu01 | CLIA Kit for Asporin (ASPN) | CLIA assay for Antigen Detection |
| ELU524Mu01 | ELISA Kit for Asporin (ASPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU524Ra01 | Recombinant Asporin (ASPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU524Ra01 | Monoclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IP. |
| PAU524Ra01 | Polyclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU524Ra01 | CLIA Kit for Asporin (ASPN) | CLIA assay for Antigen Detection |
| ELU524Ra01 | ELISA Kit for Asporin (ASPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU524Ca01 | Recombinant Asporin (ASPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU524Ca01 | Monoclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IP. |
| PAU524Ca01 | Polyclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU524Ca01 | CLIA Kit for Asporin (ASPN) | CLIA assay for Antigen Detection |
| ELU524Ca01 | ELISA Kit for Asporin (ASPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU524Po01 | Recombinant Asporin (ASPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU524Po01 | Monoclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IP. |
| PAU524Po01 | Polyclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU524Po01 | CLIA Kit for Asporin (ASPN) | CLIA assay for Antigen Detection |
| ELU524Po01 | ELISA Kit for Asporin (ASPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU524Bo01 | Recombinant Asporin (ASPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU524Bo01 | Monoclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IP. |
| PAU524Bo01 | Polyclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU524Bo01 | CLIA Kit for Asporin (ASPN) | CLIA assay for Antigen Detection |
| ELU524Bo01 | ELISA Kit for Asporin (ASPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU524Rb01 | Recombinant Asporin (ASPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU524Rb01 | Monoclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IP. |
| PAU524Rb01 | Polyclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU524Rb01 | CLIA Kit for Asporin (ASPN) | CLIA assay for Antigen Detection |
| ELU524Rb01 | ELISA Kit for Asporin (ASPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU524Mo01 | Recombinant Asporin (ASPN) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU524Mo01 | Monoclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IP. |
| PAU524Mo01 | Polyclonal Antibody to Asporin (ASPN) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU524Mo01 | CLIA Kit for Asporin (ASPN) | CLIA assay for Antigen Detection |
| ELU524Mo01 | ELISA Kit for Asporin (ASPN) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification and characterization of asporin. A novel member of the leucine-rich repeat protein family closely related to decorin and biglycan."
J. Biol. Chem. 276:12201-12211(2001) [PubMed] [Europe PMC] [Abstract]
"Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene."
Gene 275:279-286(2001) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"Expression pattern and gene characterization of asporin. A newly discovered member of the leucine-rich repeat protein family."
J. Biol. Chem. 276:12212-12221(2001) [PubMed] [Europe PMC] [Abstract]
"An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis."
Nat. Genet. 37:138-144(2005) [PubMed] [Europe PMC] [Abstract]
"Mechanisms for asporin function and regulation in articular cartilage."
J. Biol. Chem. 282:32185-32192(2007) [PubMed] [Europe PMC] [Abstract]
"Association of the asporin D14 allele with lumbar-disc degeneration in Asians."
Am. J. Hum. Genet. 82:744-747(2008) [PubMed] [Europe PMC] [Abstract]
"Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization."
Biochem. J. 423:53-59(2009) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]