Bcl2 Associated Death Promoter (BAD)

BBC2; BCL2L8; BCL2-Antagonist Of Cell Death; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death

SPN	U509
HGNC	936
MGI	1096330
PubMed	21130780
RGD	620103
UniProt	Q92934
Wiki	BAD

The Bcl-2-associated death promoter (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. It does not contain a C-terminal transmembrane domain for outer mitochondrial membrane and nuclear envelope targeting, unlike most other members of the Bcl-2 family . After activation, it is able to form a heterodimer with anti-apoptotic proteins and prevent them from stopping apoptosis. The Bcl-2-associated death promoter (BAD) protein is a member of the Bcl-2 gene family. Some members of this family are pro-apoptotic (e.g., Bax, Bak) while others are anti-apoptotic (e.g., Bcl-2, Bcl-xL). Bax/Bak are believed to initiate apoptosis by forming a pore in the mitochondrial outer membrane that allows cytochrome c to escape into the cytoplasm and activate the pro-apoptotic caspase cascade.

Reference

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Cell 87:629-638(1996) [PubMed] [Europe PMC] [Abstract]

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"The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis."
J. Biol. Chem. 276:14414-14419(2001) [PubMed] [Europe PMC] [Abstract]

"p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD."
Mol. Cell. Biol. 23:5526-5539(2003) [PubMed] [Europe PMC] [Abstract]

"Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines."
Cancer Res. 66:6741-6747(2006) [PubMed] [Europe PMC] [Abstract]

"Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis."
Cancer Sci. 98:321-328(2007) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

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Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt."
Proc. Natl. Acad. Sci. U.S.A. 108:6085-6090(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies."
Protein Sci. 9:2528-2534(2000) [PubMed] [Europe PMC] [Abstract]