Lipase, Bile Salt Dependent (BSDL)

CEL; FAP; BAL; BSSL; FAPP; LIPA; MODY8; Carboxyl Ester Lipase; Bile salt-stimulated lipase; Bucelipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase

SPN	U505
HGNC	1848
MGI	88374
PubMed	16528254
RGD	2331
UniProt	P19835
Wiki	BSDL

Bile salt dependent lipase (or BSDL), also known as carboxyl ester lipase (or CEL) is an enzyme produced by the adult pancreas and aids in the digestion of fats. Bile salt stimulated lipase (or BSSL) is an equivalent enzyme found within breast milk. BSDL has been found in the pancreatic secretions of all species in which it has been looked for. BSSL, originally discovered in the milk of humans and various other primates, has since been found in the milk of many animals including dogs, cats, rats and rabbits. More than 95% of the fat present in human milk and in infant formulas is in the form of triacylglycerols (TG). In adults TGs are mainly thought to be broken down or hydrolyzed by the colipase-dependent lipase enzyme. In the newborn, CDL activity in the duodenum is lower than in adults.

Reference

"cDNA cloning of human-milk bile-salt-stimulated lipase and evidence for its identity to pancreatic carboxylic ester hydrolase."
Eur. J. Biochem. 192:543-550(1990) [PubMed] [Europe PMC] [Abstract]

"Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase."
FEBS Lett. 276:131-134(1990) [PubMed] [Europe PMC] [Abstract]

"Structure of human milk bile salt activated lipase."
Biochemistry 30:500-510(1991) [PubMed] [Europe PMC] [Abstract]

"Genomic organization, sequence analysis, and chromosomal localization of the human carboxyl ester lipase (CEL) gene and a CEL-like (CELL) gene."
Genomics 13:630-640(1992) [PubMed] [Europe PMC] [Abstract]

"Bile salt-dependent lipase transcripts in human fetal tissues."
Biochim. Biophys. Acta 1264:141-150(1995) [PubMed] [Europe PMC] [Abstract]

"Structure and organization of the human carboxyl ester lipase locus."
Mamm. Genome 9:334-338(1998) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"Lipoamidase activity in normal and mutagenized pancreatic cholesterol esterase (bile salt-stimulated lipase)."
Biochem. J. 291:65-69(1993) [PubMed] [Europe PMC] [Abstract]

"Human milk bile-salt stimulated lipase. Sequence similarity with rat lysophospholipase and homology with the active site region of cholinesterases."
FEBS Lett. 278:190-194(1991) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of human milk bile salt-activated lipase C-tail fragment."
Biochemistry 34:10639-10644(1995) [PubMed] [Europe PMC] [Abstract]

"Structural characterization of the N-linked oligosaccharides in bile salt-stimulated lipase originated from human breast milk."
Glycobiology 9:227-234(1999) [PubMed] [Europe PMC] [Abstract]

"Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion."
J. Biol. Chem. 277:14859-14868(2002) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the catalytic domain of human bile salt activated lipase."
Protein Sci. 9:1783-1790(2000) [PubMed] [Europe PMC] [Abstract]

"Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction."
Nat. Genet. 38:54-62(2006) [PubMed] [Europe PMC] [Abstract]