Brain Specific Angiogenesis Inhibitor 1 (BAI1)

SPN	U502
HGNC	943
MGI	1933736
PubMed	21245295
RGD	1305608
UniProt	O14514
Wiki	BAI1

Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas

Reference

"A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis."
Oncogene 15:2145-2150(1997) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1."
Biochem. Biophys. Res. Commun. 247:597-604(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1."
Cytogenet. Cell Genet. 84:75-82(1999) [PubMed] [Europe PMC] [Abstract]

"Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."
J. Biol. Chem. 275:21477-21485(2000) [PubMed] [Europe PMC] [Abstract]

"Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis."
Br. J. Cancer 86:490-496(2002) [PubMed] [Europe PMC] [Abstract]

"Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells."
Neurosci. Res. 43:69-74(2002) [PubMed] [Europe PMC] [Abstract]

"Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression."
Am. J. Pathol. 162:19-27(2003) [PubMed] [Europe PMC] [Abstract]

"A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis."
EMBO J. 31:1364-1378(2012) [PubMed] [Europe PMC] [Abstract]