Calcyphosine (CAPS)

CAPS1; Thyroid Protein p24; Calcyphosin

SPN	U489
HGNC	1487
PubMed	9125191
UniProt	Q13938
Wiki	CAPS

Calcyphosin isa calcium-binding protein with 4 EF-hand domains whose synthesis and phosphorylation is upregulated by cAMP agonists in thyrocytes. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants.Calcyphosine was first described as a potentially important regulatory protein in the dog thyroid.

The deduced 189-amino acid protein has a molecular mass of about 24 kD by Western blot analysis. Human CAPS shares extensive sequence conservation with the sequences from dog and rabbit. Northern and Western blot analyses revealed that expression in human thyroid tissue is relatively lower than that in dog.

Reference

"Cloning and sequence analysis of human calcyphosine complementary DNA."
Biochim. Biophys. Acta 1352:249-252(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family."
J. Mol. Biol. 383:455-464(2008) [PubMed] [Europe PMC] [Abstract]