Cyclin Dependent Kinase Inhibitor 3 (CDKN3)

CDI1; CIP2; KAP1; CDK2-Associated Dual Specificity Phosphatase; Kinase Associated Phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting 2

SPN	U480
HGNC	1791
MGI	1919641
PubMed	23775190
RGD	1307781
UniProt	Q16667
Wiki	CDKN3

CDKN3 is an enzyme belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.CDI1 is expressed at the G1 to S transition, and the protein forms stable complexes with CDK2. In vitro, CDI1 removes phosphate from tyrosine residues in model substrates, but a mutant protein that bears a lesion in the putative active site cysteine does not. Overexpression of wildtype CDI1 delays progression through the cell cycle in yeast and HeLa cells; delay is dependent on CDI1 phosphatase activity. The gene is also symbolized CDKN3 for cyclin-dependent kinase inhibitor 3.

Reference

"Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2."
Cell 75:791-803(1993) [PubMed] [Europe PMC] [Abstract]

"KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases."
Proc. Natl. Acad. Sci. U.S.A. 91:1731-1735(1994) [PubMed] [Europe PMC] [Abstract]

"Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma."
Cancer Res. 60:4697-4700(2000) [PubMed] [Europe PMC] [Abstract]

"Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant."
Biochem. Biophys. Res. Commun. 305:311-314(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin."
Science 270:90-93(1995) [PubMed] [Europe PMC] [Abstract]

"Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression."
Mol. Cell. Biol. 20:1723-1732(2000) [PubMed] [Europe PMC] [Abstract]

"Human HTm4 is a hematopoietic cell cycle regulator."
J. Clin. Invest. 109:51-58(2002) [PubMed] [Europe PMC] [Abstract]

"Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2."
J. Biol. Chem. 280:17235-17242(2005) [PubMed] [Europe PMC] [Abstract]

"Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2."
Mol. Cell 7:615-626(2001) [PubMed] [Europe PMC] [Abstract]