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Carboxylesterase 1 (CES1)

ACAT; CEH; CES2; HMSE1; PCE1; SES1; TGH; Retinyl ester hydrolase; Serine esterase 1; Triacylglycerol hydrolase; Egasyn; Cocaine carboxylesterase; Liver Carboxylesterase 1

Carboxylesterase 1 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters.
This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Three transcript variants encoding three different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU474Hu01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU474Hu01 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
PAU474Hu01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IF.
Assay Kits CLU474Hu01 CLIA Kit for Carboxylesterase 1 (CES1) CLIA assay for Antigen Detection
ELU474Hu01 ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU474Mu01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU474Mu01 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
PAU474Mu01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IF.
Assay Kits CLU474Mu01 CLIA Kit for Carboxylesterase 1 (CES1) CLIA assay for Antigen Detection
ELU474Mu01 ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU474Ra01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU474Ra01 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
PAU474Ra01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IF.
Assay Kits CLU474Ra01 CLIA Kit for Carboxylesterase 1 (CES1) CLIA assay for Antigen Detection
ELU474Ra01 ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU474Ca01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU474Ca01 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
PAU474Ca01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IF.
Assay Kits CLU474Ca01 CLIA Kit for Carboxylesterase 1 (CES1) CLIA assay for Antigen Detection
ELU474Ca01 ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU474Po01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU474Po01 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
PAU474Po01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IF.
Assay Kits CLU474Po01 CLIA Kit for Carboxylesterase 1 (CES1) CLIA assay for Antigen Detection
ELU474Po01 ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU474Bo01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU474Bo01 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
PAU474Bo01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IF.
Assay Kits CLU474Bo01 CLIA Kit for Carboxylesterase 1 (CES1) CLIA assay for Antigen Detection
ELU474Bo01 ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU474Rb01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU474Rb01 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
PAU474Rb01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IF.
Assay Kits CLU474Rb01 CLIA Kit for Carboxylesterase 1 (CES1) CLIA assay for Antigen Detection
ELU474Rb01 ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU474Mo01 Recombinant Carboxylesterase 1 (CES1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU474Mo01 Monoclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IP.
PAU474Mo01 Polyclonal Antibody to Carboxylesterase 1 (CES1) WB; IHC; ICC; IF.
Assay Kits CLU474Mo01 CLIA Kit for Carboxylesterase 1 (CES1) CLIA assay for Antigen Detection
ELU474Mo01 ELISA Kit for Carboxylesterase 1 (CES1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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J. Biol. Chem. 266:18832-18838(1991) [PubMed] [Europe PMC] [Abstract]

"Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms."
Biochemistry 32:11606-11617(1993) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of a human carboxylesterase gene."
Genomics 17:76-82(1993) [PubMed] [Europe PMC] [Abstract]

"Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase."
Arterioscler. Thromb. 14:1346-1355(1994) [PubMed] [Europe PMC] [Abstract]

"Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C-terminus of beta-glucuronidase is involved in their interaction."
Arch. Biochem. Biophys. 372:53-61(1999) [PubMed] [Europe PMC] [Abstract]

"Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA."
Physiol. Genomics 2:1-8(2000) [PubMed] [Europe PMC] [Abstract]

"Heterologous expression, purification, and characterization of human triacylglycerol hydrolase."
Protein Expr. Purif. 24:33-42(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning, characterization and stable expression of novel human brain carboxylesterase."
FEBS Lett. 458:17-22(1999) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine."
Biochem. Pharmacol. 48:1747-1755(1994) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of retinyl ester hydrolase as a member of the non-specific carboxylesterase supergene family."
Eur. J. Biochem. 251:863-873(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular aspects of carboxylesterase isoforms in comparison with other esterases."
Toxicol. Lett. 82:439-445(1995) [PubMed] [Europe PMC] [Abstract]

"Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site."
Biochemistry 41:6679-6687(2002) [PubMed] [Europe PMC] [Abstract]

"Cloning and sequencing of a human liver carboxylesterase isoenzyme."
Life Sci. 48:PL43-PL49(1991) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning and characterization of human monocyte/macrophage serine esterase-1."
Blood 78:506-512(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning and analysis of a cDNA encoding a human liver carboxylesterase."
Gene 108:289-292(1991) [PubMed] [Europe PMC] [Abstract]

"Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin."
J. Biol. Chem. 272:14769-14775(1997) [PubMed] [Europe PMC] [Abstract]

"Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis."
Am. J. Hum. Genet. 82:1241-1248(2008) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine. From binding promiscuity to selective inhibition."
Chem. Biol. 10:341-349(2003) [PubMed] [Europe PMC] [Abstract]

"Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme."
Nat. Struct. Biol. 10:349-356(2003) [PubMed] [Europe PMC] [Abstract]