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Claudin 1 (CLDN1)

CLD1; ILVASC; SEMP1; Senescence-Associated Epithelial Membrane Protein 1

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands.
Claudin-1 is a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU460Hu01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU460Hu01 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
PAU460Hu01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IF.
Assay Kits CLU460Hu01 CLIA Kit for Claudin 1 (CLDN1) CLIA assay for Antigen Detection
ELU460Hu01 ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU460Mu01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU460Mu01 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
PAU460Mu01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IF.
Assay Kits CLU460Mu01 CLIA Kit for Claudin 1 (CLDN1) CLIA assay for Antigen Detection
ELU460Mu01 ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU460Ra01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU460Ra01 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
PAU460Ra01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IF.
Assay Kits CLU460Ra01 CLIA Kit for Claudin 1 (CLDN1) CLIA assay for Antigen Detection
ELU460Ra01 ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU460Ca01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU460Ca01 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
PAU460Ca01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IF.
Assay Kits CLU460Ca01 CLIA Kit for Claudin 1 (CLDN1) CLIA assay for Antigen Detection
ELU460Ca01 ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU460Po01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU460Po01 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
PAU460Po01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IF.
Assay Kits CLU460Po01 CLIA Kit for Claudin 1 (CLDN1) CLIA assay for Antigen Detection
ELU460Po01 ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU460Bo01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU460Bo01 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
PAU460Bo01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IF.
Assay Kits CLU460Bo01 CLIA Kit for Claudin 1 (CLDN1) CLIA assay for Antigen Detection
ELU460Bo01 ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU460Rb01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU460Rb01 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
PAU460Rb01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IF.
Assay Kits CLU460Rb01 CLIA Kit for Claudin 1 (CLDN1) CLIA assay for Antigen Detection
ELU460Rb01 ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU460Mo01 Recombinant Claudin 1 (CLDN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU460Mo01 Monoclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IP.
PAU460Mo01 Polyclonal Antibody to Claudin 1 (CLDN1) WB; IHC; ICC; IF.
Assay Kits CLU460Mo01 CLIA Kit for Claudin 1 (CLDN1) CLIA assay for Antigen Detection
ELU460Mo01 ELISA Kit for Claudin 1 (CLDN1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily."
Gene 226:285-295(1999) [PubMed] [Europe PMC] [Abstract]

"Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids."
Cytogenet. Cell Genet. 88:217-217(2000) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer."
Hum. Genet. 107:249-256(2000) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease."
Gastroenterology 127:1386-1390(2004) [PubMed] [Europe PMC] [Abstract]

"Confirmation of the origin of NISCH syndrome."
Hum. Mutat. 27:408-410(2006) [PubMed] [Europe PMC] [Abstract]

"Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry."
Nature 446:801-805(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes."
J. Invest. Dermatol. 133:1161-1169(2013) [PubMed] [Europe PMC] [Abstract]

"Production, purification and characterization of recombinant, full-length human claudin-1."
PLoS ONE 8:E64517-E64517(2013) [PubMed] [Europe PMC] [Abstract]