Carboxypeptidase M (CPM)

SPN	U451
HGNC	2311
MGI	1917824
PubMed	15066430
RGD	1310532
UniProt	P14384
Wiki	CPM_(gene

Carboxypeptidase M is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.

Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU451Hu01	Recombinant Carboxypeptidase M (CPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU451Hu01	Monoclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IP.
Antibodies	PAU451Hu01	Polyclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IF.
Assay Kits	CLU451Hu01	CLIA Kit for Carboxypeptidase M (CPM)	CLIA assay for Antigen Detection
Assay Kits	ELU451Hu01	ELISA Kit for Carboxypeptidase M (CPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU451Mu01	Recombinant Carboxypeptidase M (CPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU451Mu01	Monoclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IP.
Antibodies	PAU451Mu01	Polyclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IF.
Assay Kits	CLU451Mu01	CLIA Kit for Carboxypeptidase M (CPM)	CLIA assay for Antigen Detection
Assay Kits	ELU451Mu01	ELISA Kit for Carboxypeptidase M (CPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU451Ra01	Recombinant Carboxypeptidase M (CPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU451Ra01	Monoclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IP.
Antibodies	PAU451Ra01	Polyclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IF.
Assay Kits	CLU451Ra01	CLIA Kit for Carboxypeptidase M (CPM)	CLIA assay for Antigen Detection
Assay Kits	ELU451Ra01	ELISA Kit for Carboxypeptidase M (CPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU451Ca01	Recombinant Carboxypeptidase M (CPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU451Ca01	Monoclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IP.
Antibodies	PAU451Ca01	Polyclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IF.
Assay Kits	CLU451Ca01	CLIA Kit for Carboxypeptidase M (CPM)	CLIA assay for Antigen Detection
Assay Kits	ELU451Ca01	ELISA Kit for Carboxypeptidase M (CPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU451Po01	Recombinant Carboxypeptidase M (CPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU451Po01	Monoclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IP.
Antibodies	PAU451Po01	Polyclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IF.
Assay Kits	CLU451Po01	CLIA Kit for Carboxypeptidase M (CPM)	CLIA assay for Antigen Detection
Assay Kits	ELU451Po01	ELISA Kit for Carboxypeptidase M (CPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU451Bo01	Recombinant Carboxypeptidase M (CPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU451Bo01	Monoclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IP.
Antibodies	PAU451Bo01	Polyclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IF.
Assay Kits	CLU451Bo01	CLIA Kit for Carboxypeptidase M (CPM)	CLIA assay for Antigen Detection
Assay Kits	ELU451Bo01	ELISA Kit for Carboxypeptidase M (CPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU451Rb01	Recombinant Carboxypeptidase M (CPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU451Rb01	Monoclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IP.
Antibodies	PAU451Rb01	Polyclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IF.
Assay Kits	CLU451Rb01	CLIA Kit for Carboxypeptidase M (CPM)	CLIA assay for Antigen Detection
Assay Kits	ELU451Rb01	ELISA Kit for Carboxypeptidase M (CPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU451Mo01	Recombinant Carboxypeptidase M (CPM)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU451Mo01	Monoclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IP.
Antibodies	PAU451Mo01	Polyclonal Antibody to Carboxypeptidase M (CPM)	WB; IHC; ICC; IF.
Assay Kits	CLU451Mo01	CLIA Kit for Carboxypeptidase M (CPM)	CLIA assay for Antigen Detection
Assay Kits	ELU451Mo01	ELISA Kit for Carboxypeptidase M (CPM)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N."
J. Biol. Chem. 264:13165-13170(1989) [PubMed] [Europe PMC] [Abstract]

"Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes."
Diabetes 50:204-208(2001) [PubMed] [Europe PMC] [Abstract]

"Molecular structure and alternative splicing of the human carboxypeptidase M gene."
Biol. Chem. 383:263-269(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring."
Biochem. J. 370:567-578(2003) [PubMed] [Europe PMC] [Abstract]

"Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins."
Mol. Cell. Proteomics 2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract]

"Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity."
J. Mol. Biol. 338:257-269(2004) [PubMed] [Europe PMC] [Abstract]