Cryptochrome 1 (CRY1)

PHLL1; Photolyase-like 1

SPN	U441
HGNC	2384
MGI	1270841
PubMed	21236481
RGD	735083
UniProt	Q16526
Wiki	Cryptochrome

CRY proteins belong to a superfamily of flavoproteins that occurs in all kingdoms of life. The structure has a fold very similar to photolyase, with a single molecule of FAD noncovalently bound to the protein. These proteins have variable lengths and surfaces on the C-terminal end when compared to one another, due to the lack of DNA repair enzymes which ultimately results in changes in genome and appearance. The Ramachandran plot, shows that the secondary structure of the CRY1 protein is primarily in a right-handed alpha helix conformation with little to no steric overlap.The structure of CRY1 is almost entirely made up of alpha helicies, with remaining portions in loops and has few beta sheets present in the molecule. The molecule is arranged as an orthogonal bundle.

Reference

"Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins."
Biochemistry 35:13871-13877(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors."
Genomics 37:177-182(1996) [PubMed] [Europe PMC] [Abstract]

"Similarity among the Drosophila (6-4)photolyase, a human photolyase homolog, and the DNA photolyase-blue-light photoreceptor family."
Science 272:109-112(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Light-independent role of CRY1 and CRY2 in the mammalian circadian clock."
Science 286:768-771(1999) [PubMed] [Europe PMC] [Abstract]

"A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation."
Biochem. Biophys. Res. Commun. 313:117-124(2004) [PubMed] [Europe PMC] [Abstract]

"Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5."
Proc. Natl. Acad. Sci. U.S.A. 103:10467-10472(2006) [PubMed] [Europe PMC] [Abstract]

"SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins."
Science 316:900-904(2007) [PubMed] [Europe PMC] [Abstract]

"Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis."
Nat. Med. 16:1152-1156(2010) [PubMed] [Europe PMC] [Abstract]

"Biochemical analysis of the canonical model for the mammalian circadian clock."
J. Biol. Chem. 286:25891-25902(2011) [PubMed] [Europe PMC] [Abstract]

"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]

"Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene."
PLoS ONE 7:E48152-E48152(2012) [PubMed] [Europe PMC] [Abstract]

"Metabolism and the circadian clock converge."
Physiol. Rev. 93:107-135(2013) [PubMed] [Europe PMC] [Abstract]

"Molecular architecture of the mammalian circadian clock."
Trends Cell Biol. 24:90-99(2014) [PubMed] [Europe PMC] [Abstract]