Cathepsin E (CTSE)

CTS-E; CATE

SPN	U438
HGNC	2530
MGI	107361
PubMed	23814481
RGD	2446
UniProt	P14091
Wiki	Cathepsin_E

Cathepsin E is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach.

It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU438Hu01	Recombinant Cathepsin E (CTSE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU438Hu01	Monoclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IP.
Antibodies	PAU438Hu01	Polyclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IF.
Assay Kits	CLU438Hu01	CLIA Kit for Cathepsin E (CTSE)	CLIA assay for Antigen Detection
Assay Kits	ELU438Hu01	ELISA Kit for Cathepsin E (CTSE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU438Mu01	Recombinant Cathepsin E (CTSE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU438Mu01	Monoclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IP.
Antibodies	PAU438Mu01	Polyclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IF.
Assay Kits	CLU438Mu01	CLIA Kit for Cathepsin E (CTSE)	CLIA assay for Antigen Detection
Assay Kits	ELU438Mu01	ELISA Kit for Cathepsin E (CTSE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU438Ra01	Recombinant Cathepsin E (CTSE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU438Ra01	Monoclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IP.
Antibodies	PAU438Ra01	Polyclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IF.
Assay Kits	CLU438Ra01	CLIA Kit for Cathepsin E (CTSE)	CLIA assay for Antigen Detection
Assay Kits	ELU438Ra01	ELISA Kit for Cathepsin E (CTSE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU438Ca01	Recombinant Cathepsin E (CTSE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU438Ca01	Monoclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IP.
Antibodies	PAU438Ca01	Polyclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IF.
Assay Kits	CLU438Ca01	CLIA Kit for Cathepsin E (CTSE)	CLIA assay for Antigen Detection
Assay Kits	ELU438Ca01	ELISA Kit for Cathepsin E (CTSE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU438Po01	Recombinant Cathepsin E (CTSE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU438Po01	Monoclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IP.
Antibodies	PAU438Po01	Polyclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IF.
Assay Kits	CLU438Po01	CLIA Kit for Cathepsin E (CTSE)	CLIA assay for Antigen Detection
Assay Kits	ELU438Po01	ELISA Kit for Cathepsin E (CTSE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU438Bo01	Recombinant Cathepsin E (CTSE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU438Bo01	Monoclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IP.
Antibodies	PAU438Bo01	Polyclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IF.
Assay Kits	CLU438Bo01	CLIA Kit for Cathepsin E (CTSE)	CLIA assay for Antigen Detection
Assay Kits	ELU438Bo01	ELISA Kit for Cathepsin E (CTSE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU438Rb01	Recombinant Cathepsin E (CTSE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU438Rb01	Monoclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IP.
Antibodies	PAU438Rb01	Polyclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IF.
Assay Kits	CLU438Rb01	CLIA Kit for Cathepsin E (CTSE)	CLIA assay for Antigen Detection
Assay Kits	ELU438Rb01	ELISA Kit for Cathepsin E (CTSE)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU438Mo01	Recombinant Cathepsin E (CTSE)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU438Mo01	Monoclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IP.
Antibodies	PAU438Mo01	Polyclonal Antibody to Cathepsin E (CTSE)	WB; IHC; ICC; IF.
Assay Kits	CLU438Mo01	CLIA Kit for Cathepsin E (CTSE)	CLIA assay for Antigen Detection
Assay Kits	ELU438Mo01	ELISA Kit for Cathepsin E (CTSE)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases."
J. Biol. Chem. 264:16748-16753(1989) [PubMed] [Europe PMC] [Abstract]

"Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32."
J. Biol. Chem. 267:1609-1614(1992) [PubMed] [Europe PMC] [Abstract]

"Subcellular localization and targeting of cathepsin E."
J. Biol. Chem. 269:31259-31266(1994) [PubMed] [Europe PMC] [Abstract]

"An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells."
Biochim. Biophys. Acta 1625:203-206(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation and biochemical characterization of procathepsin E from human erythrocyte membranes."
Arch. Biochem. Biophys. 304:352-358(1993) [PubMed] [Europe PMC] [Abstract]

"Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E."
Biochem. Biophys. Res. Commun. 168:878-885(1990) [PubMed] [Europe PMC] [Abstract]

"Monomeric human cathepsin E."
FEBS Lett. 366:72-74(1995) [PubMed] [Europe PMC] [Abstract]

"Regulation of cathepsin E expression during human B cell differentiation in vitro."
Eur. J. Immunol. 26:1838-1843(1996) [PubMed] [Europe PMC] [Abstract]

"Regulation of human and mouse procathepsin E gene expression."
Eur. J. Biochem. 268:2658-2668(2001) [PubMed] [Europe PMC] [Abstract]