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Catalase (CAT)

Catalase is a common enzyme found in nearly all living organisms which are exposed to oxygen, where it functions to catalyze the decomposition of hydrogen peroxide to water and oxygen.Catalase has one of the highest turnover numbers of all enzymes; one molecule of catalase can convert millions of molecules of hydrogen peroxide to water and oxygen per second.
Catalase is a tetramer of four polypeptide chains, each over 500 amino acids long. It contains four porphyrin heme (iron) groups that allow the enzyme to react with the hydrogen peroxide. The optimum pH for human catalase is approximately 7,and has a fairly broad maximum (the rate of reaction does not change appreciably at pHs between 6.8 and 7.5).

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU430Hu01 Recombinant Catalase (CAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU430Hu01 Monoclonal Antibody to Catalase (CAT) WB; IHC; ICC; IP.
PAU430Hu01 Polyclonal Antibody to Catalase (CAT) WB; IHC; ICC; IF.
Assay Kits CLU430Hu01 CLIA Kit for Catalase (CAT) CLIA assay for Antigen Detection
ELU430Hu01 ELISA Kit for Catalase (CAT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU430Mu01 Recombinant Catalase (CAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU430Mu01 Monoclonal Antibody to Catalase (CAT) WB; IHC; ICC; IP.
PAU430Mu01 Polyclonal Antibody to Catalase (CAT) WB; IHC; ICC; IF.
Assay Kits CLU430Mu01 CLIA Kit for Catalase (CAT) CLIA assay for Antigen Detection
ELU430Mu01 ELISA Kit for Catalase (CAT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU430Ra01 Recombinant Catalase (CAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU430Ra01 Monoclonal Antibody to Catalase (CAT) WB; IHC; ICC; IP.
PAU430Ra01 Polyclonal Antibody to Catalase (CAT) WB; IHC; ICC; IF.
Assay Kits CLU430Ra01 CLIA Kit for Catalase (CAT) CLIA assay for Antigen Detection
ELU430Ra01 ELISA Kit for Catalase (CAT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU430Ca01 Recombinant Catalase (CAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU430Ca01 Monoclonal Antibody to Catalase (CAT) WB; IHC; ICC; IP.
PAU430Ca01 Polyclonal Antibody to Catalase (CAT) WB; IHC; ICC; IF.
Assay Kits CLU430Ca01 CLIA Kit for Catalase (CAT) CLIA assay for Antigen Detection
ELU430Ca01 ELISA Kit for Catalase (CAT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU430Po01 Recombinant Catalase (CAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU430Po01 Monoclonal Antibody to Catalase (CAT) WB; IHC; ICC; IP.
PAU430Po01 Polyclonal Antibody to Catalase (CAT) WB; IHC; ICC; IF.
Assay Kits CLU430Po01 CLIA Kit for Catalase (CAT) CLIA assay for Antigen Detection
ELU430Po01 ELISA Kit for Catalase (CAT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU430Bo01 Recombinant Catalase (CAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU430Bo01 Monoclonal Antibody to Catalase (CAT) WB; IHC; ICC; IP.
PAU430Bo01 Polyclonal Antibody to Catalase (CAT) WB; IHC; ICC; IF.
Assay Kits CLU430Bo01 CLIA Kit for Catalase (CAT) CLIA assay for Antigen Detection
ELU430Bo01 ELISA Kit for Catalase (CAT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU430Rb01 Recombinant Catalase (CAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU430Rb01 Monoclonal Antibody to Catalase (CAT) WB; IHC; ICC; IP.
PAU430Rb01 Polyclonal Antibody to Catalase (CAT) WB; IHC; ICC; IF.
Assay Kits CLU430Rb01 CLIA Kit for Catalase (CAT) CLIA assay for Antigen Detection
ELU430Rb01 ELISA Kit for Catalase (CAT) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU430Mo01 Recombinant Catalase (CAT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU430Mo01 Monoclonal Antibody to Catalase (CAT) WB; IHC; ICC; IP.
PAU430Mo01 Polyclonal Antibody to Catalase (CAT) WB; IHC; ICC; IF.
Assay Kits CLU430Mo01 CLIA Kit for Catalase (CAT) CLIA assay for Antigen Detection
ELU430Mo01 ELISA Kit for Catalase (CAT) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Isolation and characterization of the human catalase gene."
Nucleic Acids Res. 14:5321-5335(1986) [PubMed] [Europe PMC] [Abstract]

"cDNA sequence coding for human kidney catalase."
Nucleic Acids Res. 14:5561-5562(1986) [PubMed] [Europe PMC] [Abstract]

"Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and arginine-rich peptides into mammalian cells."
Free Radic. Biol. Med. 31:1509-1519(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Vulnerability of the human airway epithelium to hyperoxia. Constitutive expression of the catalase gene in human bronchial epithelial cells despite oxidant stress."
J. Clin. Invest. 93:297-302(1994) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"A human erythrocyte-derived growth-promoting factor with a wide target cell spectrum: identification as catalase."
Cancer Res. 55:1586-1589(1995) [PubMed] [Europe PMC] [Abstract]

"Isolation of human fibroblast catalase cDNA clones. Sequence of clones derived from spliced and unspliced mRNA."
J. Biol. Chem. 259:13819-13823(1984) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAR-2007) to UniProtKB

"Molecular analysis of human acatalasemia. Identification of a splicing mutation."
J. Mol. Biol. 211:383-393(1990) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of human erythrocyte catalase."
Acta Crystallogr. D 56:241-245(2000) [PubMed] [Europe PMC] [Abstract]

"Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism."
J. Mol. Biol. 296:295-309(2000) [PubMed] [Europe PMC] [Abstract]

"Structure of tetragonal crystals of human erythrocyte catalase."
Acta Crystallogr. D 57:1-7(2001) [PubMed] [Europe PMC] [Abstract]