Death Associated Protein Kinase 1 (DAPK1)

SPN	U419
HGNC	2674
MGI	1916885
PubMed	17540169
RGD	1311629
UniProt	P53355
Wiki	DAPK1

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.In melanocytic cells DAPK1 gene expression may be regulated by MITF

DAP is expressed as a single 2.4-kb mRNA that codes for a basic proline-rich 15-kD protein. DAPK is transcribed into a single 6.3-kb mRNA encoded for a structurally unique 160-kD calmodulin-dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites.

Reference

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Genes Dev. 9:15-30(1995) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis."
Mol. Cell. Biol. 20:1044-1054(2000) [PubMed] [Europe PMC] [Abstract]

"The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism."
J. Biol. Chem. 276:47460-47467(2001) [PubMed] [Europe PMC] [Abstract]

"DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death."
J. Cell Biol. 157:455-468(2002) [PubMed] [Europe PMC] [Abstract]

"Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18."
J. Biol. Chem. 278:26265-26274(2003) [PubMed] [Europe PMC] [Abstract]

"Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions."
Mol. Cell. Biol. 24:8611-8626(2004) [PubMed] [Europe PMC] [Abstract]

"Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway."
Biotechnol. Lett. 27:1011-1015(2005) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling."
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"Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK."
EMBO J. 24:294-304(2005) [PubMed] [Europe PMC] [Abstract]

"The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase."
EMBO J. 24:1192-1201(2005) [PubMed] [Europe PMC] [Abstract]

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"Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation."
J. Biol. Chem. 281:39033-39040(2006) [PubMed] [Europe PMC] [Abstract]

"DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress."
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"DAP kinase mediates the phosphorylation of tropomyosin-1 downstream of the ERK pathway, which regulates the formation of stress fibers in response to oxidative stress."
J. Cell Sci. 120:3666-3677(2007) [PubMed] [Europe PMC] [Abstract]

"An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing."
FEBS J. 275:2574-2584(2008) [PubMed] [Europe PMC] [Abstract]

"DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing."
J. Biol. Chem. 283:9999-10014(2008) [PubMed] [Europe PMC] [Abstract]

"DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression."
Mol. Cell 32:371-382(2008) [PubMed] [Europe PMC] [Abstract]

"DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy."
EMBO Rep. 10:285-292(2009) [PubMed] [Europe PMC] [Abstract]

"Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling."
J. Biol. Chem. 284:334-344(2009) [PubMed] [Europe PMC] [Abstract]

"The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses."
EMBO J. 29:1748-1761(2010) [PubMed] [Europe PMC] [Abstract]

"Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death."
FEBS J. 277:48-57(2010) [PubMed] [Europe PMC] [Abstract]

"Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function."
Mol. Cell 42:147-159(2011) [PubMed] [Europe PMC] [Abstract]

"New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform."
PLoS ONE 6:E17344-E17344(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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"Complex structure of kinase domain of DAP kinase with staurosporine."
Submitted (APR-2006) to the PDB data bank

"Recognition of human death-associated protein kinases by calmodulin."
Submitted (JUL-2006) to the PDB data bank

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]