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Docking Protein 1 (DOK1)

P62DOK; Downstream Of Tyrosine Kinase 1

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML.
Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU414Hu01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU414Hu01 Monoclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
PAU414Hu01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IF.
Assay Kits CLU414Hu01 CLIA Kit for Docking Protein 1 (DOK1) CLIA assay for Antigen Detection
ELU414Hu01 ELISA Kit for Docking Protein 1 (DOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU414Mu01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU414Mu01 Monoclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
PAU414Mu01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IF.
Assay Kits CLU414Mu01 CLIA Kit for Docking Protein 1 (DOK1) CLIA assay for Antigen Detection
ELU414Mu01 ELISA Kit for Docking Protein 1 (DOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU414Ra01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU414Ra01 Monoclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
PAU414Ra01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IF.
Assay Kits CLU414Ra01 CLIA Kit for Docking Protein 1 (DOK1) CLIA assay for Antigen Detection
ELU414Ra01 ELISA Kit for Docking Protein 1 (DOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU414Ca01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU414Ca01 Monoclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
PAU414Ca01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IF.
Assay Kits CLU414Ca01 CLIA Kit for Docking Protein 1 (DOK1) CLIA assay for Antigen Detection
ELU414Ca01 ELISA Kit for Docking Protein 1 (DOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU414Po01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU414Po01 Monoclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
PAU414Po01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IF.
Assay Kits CLU414Po01 CLIA Kit for Docking Protein 1 (DOK1) CLIA assay for Antigen Detection
ELU414Po01 ELISA Kit for Docking Protein 1 (DOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU414Bo01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU414Bo01 Monoclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
PAU414Bo01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IF.
Assay Kits CLU414Bo01 CLIA Kit for Docking Protein 1 (DOK1) CLIA assay for Antigen Detection
ELU414Bo01 ELISA Kit for Docking Protein 1 (DOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU414Rb01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU414Rb01 Monoclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
PAU414Rb01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IF.
Assay Kits CLU414Rb01 CLIA Kit for Docking Protein 1 (DOK1) CLIA assay for Antigen Detection
ELU414Rb01 ELISA Kit for Docking Protein 1 (DOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU414Mo01 Recombinant Docking Protein 1 (DOK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU414Mo01 Monoclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IP.
PAU414Mo01 Polyclonal Antibody to Docking Protein 1 (DOK1) WB; IHC; ICC; IF.
Assay Kits CLU414Mo01 CLIA Kit for Docking Protein 1 (DOK1) CLIA assay for Antigen Detection
ELU414Mo01 ELISA Kit for Docking Protein 1 (DOK1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells."
Cell 88:197-204(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a truncated p62Dok1 isoform, p22Dokdel."
Eur. J. Immunogenet. 27:145-148(2000) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt."
J. Biol. Chem. 276:42843-42850(2001) [PubMed] [Europe PMC] [Abstract]

"DOK4 and DOK5: new Dok-related genes expressed in human T cells."
Genes Immun. 4:40-45(2003) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Targeted mass spectrometric analysis of N-terminally truncated isoforms generated via alternative translation initiation."
FEBS Lett. 583:2441-2445(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate Dok1."
FEBS J. 280:4539-4559(2013) [PubMed] [Europe PMC] [Abstract]

"An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding."
J. Biol. Chem. 283:5420-5426(2008) [PubMed] [Europe PMC] [Abstract]