Diacylglycerol Kinase Alpha (DGKa)
DGK-A; DAGK; DAGK1; DGK-alpha; 80 kDa diacylglycerol kinase; Diglyceride kinase alpha
Diacylglycerol kinase alpha is an enzyme belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.Diacylglycerol (DAG) functions in intracellular signaling pathways as an allosteric activator of protein kinase C (PKC). In addition, DAG appears to play a role in regulating RAS and RHO family proteins by activating the guanine nucleotide exchange factors VAV and RASGRP1.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU413Hu01 | Recombinant Diacylglycerol Kinase Alpha (DGKa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU413Hu01 | Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IP. |
| PAU413Hu01 | Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU413Hu01 | CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) | CLIA assay for Antigen Detection |
| ELU413Hu01 | ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU413Mu01 | Recombinant Diacylglycerol Kinase Alpha (DGKa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU413Mu01 | Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IP. |
| PAU413Mu01 | Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU413Mu01 | CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) | CLIA assay for Antigen Detection |
| ELU413Mu01 | ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU413Ra01 | Recombinant Diacylglycerol Kinase Alpha (DGKa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU413Ra01 | Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IP. |
| PAU413Ra01 | Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU413Ra01 | CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) | CLIA assay for Antigen Detection |
| ELU413Ra01 | ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU413Ca01 | Recombinant Diacylglycerol Kinase Alpha (DGKa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU413Ca01 | Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IP. |
| PAU413Ca01 | Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU413Ca01 | CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) | CLIA assay for Antigen Detection |
| ELU413Ca01 | ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU413Po01 | Recombinant Diacylglycerol Kinase Alpha (DGKa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU413Po01 | Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IP. |
| PAU413Po01 | Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU413Po01 | CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) | CLIA assay for Antigen Detection |
| ELU413Po01 | ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU413Bo01 | Recombinant Diacylglycerol Kinase Alpha (DGKa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU413Bo01 | Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IP. |
| PAU413Bo01 | Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU413Bo01 | CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) | CLIA assay for Antigen Detection |
| ELU413Bo01 | ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU413Rb01 | Recombinant Diacylglycerol Kinase Alpha (DGKa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU413Rb01 | Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IP. |
| PAU413Rb01 | Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU413Rb01 | CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) | CLIA assay for Antigen Detection |
| ELU413Rb01 | ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU413Mo01 | Recombinant Diacylglycerol Kinase Alpha (DGKa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU413Mo01 | Monoclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IP. |
| PAU413Mo01 | Polyclonal Antibody to Diacylglycerol Kinase Alpha (DGKa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU413Mo01 | CLIA Kit for Diacylglycerol Kinase Alpha (DGKa) | CLIA assay for Antigen Detection |
| ELU413Mo01 | ELISA Kit for Diacylglycerol Kinase Alpha (DGKa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Purification, cDNA-cloning and expression of human diacylglycerol kinase."
FEBS Lett. 275:151-158(1990) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12."
Mamm. Genome 5:123-124(1994) [PubMed] [Europe PMC] [Abstract]
"Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis."
Genomics 22:246-247(1994) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"NMR structure of diacylglycerol kinase alpha, NESGC target HR532."
Submitted (JAN-2005) to the PDB data bank