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Dymeclin (DYM)

DMC; SMC; Dyggve-Melchior-Clausen syndrome protein

Dymeclin isa protein which is necessary for normal skeletal development and brain function. Mutations in this gene are associated with two types of recessive osteochondrodysplasia, Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia, which involve both skeletal defects and mental retardation.
Permeabilization assays revealed that dymeclin is not a transmembrane but a peripheral protein of the Golgi apparatus as it can be completely released from the Golgi after permeabilization of the plasma membrane. Time-lapse microscopy of living cells showed that dymeclin shuttled between the cytosol and the Golgi apparatus in a highly dynamic manner and recognized specifically a subset of mature Golgi membranes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU410Hu01 Recombinant Dymeclin (DYM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU410Hu01 Monoclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IP.
PAU410Hu01 Polyclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IF.
Assay Kits CLU410Hu01 CLIA Kit for Dymeclin (DYM) CLIA assay for Antigen Detection
ELU410Hu01 ELISA Kit for Dymeclin (DYM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU410Mu01 Recombinant Dymeclin (DYM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU410Mu01 Monoclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IP.
PAU410Mu01 Polyclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IF.
Assay Kits CLU410Mu01 CLIA Kit for Dymeclin (DYM) CLIA assay for Antigen Detection
ELU410Mu01 ELISA Kit for Dymeclin (DYM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU410Ra01 Recombinant Dymeclin (DYM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU410Ra01 Monoclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IP.
PAU410Ra01 Polyclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IF.
Assay Kits CLU410Ra01 CLIA Kit for Dymeclin (DYM) CLIA assay for Antigen Detection
ELU410Ra01 ELISA Kit for Dymeclin (DYM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU410Ca01 Recombinant Dymeclin (DYM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU410Ca01 Monoclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IP.
PAU410Ca01 Polyclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IF.
Assay Kits CLU410Ca01 CLIA Kit for Dymeclin (DYM) CLIA assay for Antigen Detection
ELU410Ca01 ELISA Kit for Dymeclin (DYM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU410Po01 Recombinant Dymeclin (DYM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU410Po01 Monoclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IP.
PAU410Po01 Polyclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IF.
Assay Kits CLU410Po01 CLIA Kit for Dymeclin (DYM) CLIA assay for Antigen Detection
ELU410Po01 ELISA Kit for Dymeclin (DYM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU410Bo01 Recombinant Dymeclin (DYM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU410Bo01 Monoclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IP.
PAU410Bo01 Polyclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IF.
Assay Kits CLU410Bo01 CLIA Kit for Dymeclin (DYM) CLIA assay for Antigen Detection
ELU410Bo01 ELISA Kit for Dymeclin (DYM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU410Rb01 Recombinant Dymeclin (DYM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU410Rb01 Monoclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IP.
PAU410Rb01 Polyclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IF.
Assay Kits CLU410Rb01 CLIA Kit for Dymeclin (DYM) CLIA assay for Antigen Detection
ELU410Rb01 ELISA Kit for Dymeclin (DYM) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU410Mo01 Recombinant Dymeclin (DYM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU410Mo01 Monoclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IP.
PAU410Mo01 Polyclonal Antibody to Dymeclin (DYM) WB; IHC; ICC; IF.
Assay Kits CLU410Mo01 CLIA Kit for Dymeclin (DYM) CLIA assay for Antigen Detection
ELU410Mo01 ELISA Kit for Dymeclin (DYM) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Mutations in a novel gene dymeclin (FLJ20071) are responsible for Dyggve-Melchior-Clausen syndrome."
Hum. Mol. Genet. 12:357-364(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The gene responsible for Dyggve-Melchior-Clausen syndrome encodes a novel peripheral membrane protein dynamically associated with the Golgi apparatus."
Hum. Mol. Genet. 18:440-453(2009) [PubMed] [Europe PMC] [Abstract]

"Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development."
Hum. Mutat. 32:231-239(2011) [PubMed] [Europe PMC] [Abstract]

"Mental retardation and abnormal skeletal development (Dyggve-Melchior-Clausen dysplasia) due to mutations in a novel, evolutionarily conserved gene."
Am. J. Hum. Genet. 72:419-428(2003) [PubMed] [Europe PMC] [Abstract]

"Portuguese case of Smith-McCort syndrome caused by a new mutation in the dymeclin (FLJ20071) gene."
Clin. Dysmorphol. 18:41-44(2009) [PubMed] [Europe PMC] [Abstract]