Flavin Containing Monooxygenase 2, Non Functional (FMO2)
FMO1B1; Dimethylaniline oxidase 2; Pulmonary flavin-containing monooxygenase 2; Dimethylaniline monooxygenase [N-oxide-forming] 2
The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded.
Dimethylaniline monooxygenase [N-oxide-forming] 2 represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU366Hu01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU366Hu01 | Monoclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| PAU366Hu01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU366Hu01 | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA assay for Antigen Detection |
| ELU366Hu01 | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU366Mu01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU366Mu01 | Monoclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| PAU366Mu01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU366Mu01 | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA assay for Antigen Detection |
| ELU366Mu01 | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU366Ra01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU366Ra01 | Monoclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| PAU366Ra01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU366Ra01 | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA assay for Antigen Detection |
| ELU366Ra01 | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU366Ca01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU366Ca01 | Monoclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| PAU366Ca01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU366Ca01 | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA assay for Antigen Detection |
| ELU366Ca01 | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU366Po01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU366Po01 | Monoclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| PAU366Po01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU366Po01 | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA assay for Antigen Detection |
| ELU366Po01 | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU366Bo01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU366Bo01 | Monoclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| PAU366Bo01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU366Bo01 | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA assay for Antigen Detection |
| ELU366Bo01 | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU366Rb01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU366Rb01 | Monoclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| PAU366Rb01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU366Rb01 | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA assay for Antigen Detection |
| ELU366Rb01 | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU366Mo01 | Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU366Mo01 | Monoclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IP. |
| PAU366Mo01 | Polyclonal Antibody to Flavin Containing Monooxygenase 2, Non Functional (FMO2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU366Mo01 | CLIA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | CLIA assay for Antigen Detection |
| ELU366Mo01 | ELISA Kit for Flavin Containing Monooxygenase 2, Non Functional (FMO2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein."
J. Biol. Chem. 273:30599-30607(1998) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans."
Toxicol. Appl. Pharmacol. 168:216-224(2000) [PubMed] [Europe PMC] [Abstract]
"In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."
J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
"Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans."
Drug Metab. Dispos. 31:187-193(2003) [PubMed] [Europe PMC] [Abstract]
"The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa."
Pharmacogenet. Genomics 18:877-886(2008) [PubMed] [Europe PMC] [Abstract]