Ferroportin (FPN)

SLC40A1; FPN1; HFE4; IREG1; MTP1; SLC11A3; Solute Carrier Family 40,Member 1; Iron-Regulated Transporter

SPN	U359
HGNC	10909
MGI	1315204
PubMed	16054057
UniProt	Q9NP59
Wiki	Ferroportin

Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of it. Recent research suggests that ferroportin is inhibited by hepcidin, which therefore is the "master regulator" of human iron metabolism. Hepcidin binds to ferroportin, and results in the internalisation of ferroportin within the cell, followed by degradation by the proteasome. This results in retention of iron within the cell, and a reduction in iron levels within the plasma. This is part of the mechanism that causes anaemia of chronic disease; hepcidin is released from the liver in response to inflammatory cytokines, namely interleukin-6, which results in an increased hepcidin concentration and a consequent decrease in plasma iron levels.

Reference

"A novel mammalian iron-regulated protein involved in intracellular iron metabolism."
J. Biol. Chem. 275:19906-19912(2000) [PubMed] [Europe PMC] [Abstract]

"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation."
Mol. Cell 5:299-309(2000) [PubMed] [Europe PMC] [Abstract]

"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter."
Nature 403:776-781(2000) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of genes implicated in iron regulation in individuals presenting with primary iron overload."
Hum. Genet. 115:409-417(2004) [PubMed] [Europe PMC] [Abstract]

"Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."
Biochim. Biophys. Acta 1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]

"Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene."
J. Clin. Invest. 108:619-623(2001) [PubMed] [Europe PMC] [Abstract]

"A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis."
Nat. Genet. 28:213-214(2001) [PubMed] [Europe PMC] [Abstract]

"Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis."
Blood 100:692-694(2002) [PubMed] [Europe PMC] [Abstract]

"Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3)."
Blood 100:695-697(2002) [PubMed] [Europe PMC] [Abstract]

"A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4."
Blood 100:733-734(2002) [PubMed] [Europe PMC] [Abstract]

"Genetic hyperferritinaemia and reticuloendothelial iron overload associated with a three base pair deletion in the coding region of the ferroportin gene (SLC11A3)."
Br. J. Haematol. 119:539-546(2002) [PubMed] [Europe PMC] [Abstract]

"Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (SLC11A3) mutations."
Blood 102:1904-1910(2003) [PubMed] [Europe PMC] [Abstract]

"Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene."
Blood Cells Mol. Dis. 31:299-304(2003) [PubMed] [Europe PMC] [Abstract]

"A novel mutation in ferroportin1 is associated with haemochromatosis in a Solomon Islands patient."
Gut 52:1215-1217(2003) [PubMed] [Europe PMC] [Abstract]

"Autosomal dominant reticuloendothelial iron overload (HFE type 4) due to a new missense mutation in the FERROPORTIN 1 gene (SLC11A3) in a large French-Canadian family."
Haematologica 88:824-826(2003) [PubMed] [Europe PMC] [Abstract]

"Novel mutation in ferroportin 1 gene is associated with autosomal dominant iron overload."
J. Hepatol. 39:286-289(2003) [PubMed] [Europe PMC] [Abstract]

"The ferroportin disease."
Blood Cells Mol. Dis. 32:131-138(2004) [PubMed] [Europe PMC] [Abstract]

"Recent advances in understanding haemochromatosis: a transition state."
J. Med. Genet. 41:721-730(2004) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Med. Genet. 41:959-959(2004)

"Genetic and clinical heterogeneity of ferroportin disease."
Br. J. Haematol. 131:663-670(2005) [PubMed] [Europe PMC] [Abstract]

Erratum
Br. J. Haematol. 132:806-806(2006)