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Grancalcin (GCA)

GCL; EF Hand Calcium Binding Protein

Grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2.
Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU352Hu01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU352Hu01 Monoclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
PAU352Hu01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IF.
Assay Kits CLU352Hu01 CLIA Kit for Grancalcin (GCA) CLIA assay for Antigen Detection
ELU352Hu01 ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU352Mu01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU352Mu01 Monoclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
PAU352Mu01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IF.
Assay Kits CLU352Mu01 CLIA Kit for Grancalcin (GCA) CLIA assay for Antigen Detection
ELU352Mu01 ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU352Ra01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU352Ra01 Monoclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
PAU352Ra01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IF.
Assay Kits CLU352Ra01 CLIA Kit for Grancalcin (GCA) CLIA assay for Antigen Detection
ELU352Ra01 ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU352Ca01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU352Ca01 Monoclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
PAU352Ca01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IF.
Assay Kits CLU352Ca01 CLIA Kit for Grancalcin (GCA) CLIA assay for Antigen Detection
ELU352Ca01 ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU352Po01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU352Po01 Monoclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
PAU352Po01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IF.
Assay Kits CLU352Po01 CLIA Kit for Grancalcin (GCA) CLIA assay for Antigen Detection
ELU352Po01 ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU352Bo01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU352Bo01 Monoclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
PAU352Bo01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IF.
Assay Kits CLU352Bo01 CLIA Kit for Grancalcin (GCA) CLIA assay for Antigen Detection
ELU352Bo01 ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU352Rb01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU352Rb01 Monoclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
PAU352Rb01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IF.
Assay Kits CLU352Rb01 CLIA Kit for Grancalcin (GCA) CLIA assay for Antigen Detection
ELU352Rb01 ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU352Mo01 Recombinant Grancalcin (GCA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU352Mo01 Monoclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IP.
PAU352Mo01 Polyclonal Antibody to Grancalcin (GCA) WB; IHC; ICC; IF.
Assay Kits CLU352Mo01 CLIA Kit for Grancalcin (GCA) CLIA assay for Antigen Detection
ELU352Mo01 ELISA Kit for Grancalcin (GCA) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes."
J. Biol. Chem. 267:2928-2933(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils."
Biochem. J. 286:549-554(1992) [PubMed] [Europe PMC] [Abstract]

"Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner."
J. Biol. Chem. 276:17762-17769(2001) [PubMed] [Europe PMC] [Abstract]

"The PEF family proteins sorcin and grancalcin interact in vivo and in vitro."
FEBS Lett. 545:151-154(2003) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human grancalcin, a member of the penta-EF-hand protein family."
J. Mol. Biol. 300:1271-1281(2000) [PubMed] [Europe PMC] [Abstract]

"Structure of Ca(2+)-loaded human grancalcin."
Acta Crystallogr. D 57:1843-1849(2001) [PubMed] [Europe PMC] [Abstract]