Hedgehog Interacting Protein (HHIP)

HIP

SPN	U325
HGNC	14866
MGI	1341847
PubMed	15754313
RGD	1564108
UniProt	Q96QV1
Wiki	HHIP

Hedgehog-interacting protein is a protein similar to the mouse hedgehog-interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development. Hip cDNA encodes a type I transmembrane glycoprotein, which is expressed in all hedgehog target tissues and binds all 3 mammalian hedgehog proteins with an affinity similar to that of the Ptc protein. Hip expression is upregulated in response to Hh signaling. Ectopic expression of Hip in transgenic mice results in severe skeletal defects similar to those observed in Indian hedgehog (IHH) mutants, demonstrating that Hip is involved in the attenuation of hedgehog signaling.

Reference

"Determination of the chromosomal location and genomic structure of the Hedgehog-interacting protein gene, and analysis of its role in holoprosencephaly."
Gene Funct. Dis. 1:119-127(2000)

"The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3."
Cytogenet. Cell Genet. 92:300-303(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Comparative biological responses to human Sonic, Indian, and Desert hedgehog."
Mech. Dev. 106:107-117(2001) [PubMed] [Europe PMC] [Abstract]

"The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling."
Nat. Struct. Mol. Biol. 16:691-697(2009) [PubMed] [Europe PMC] [Abstract]

"Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP."
Nat. Struct. Mol. Biol. 16:698-703(2009) [PubMed] [Europe PMC] [Abstract]