Homeodomain Interacting Protein Kinase 1 (HIPK1)

Myak; Nbak2; Nuclear body-associated kinase 2

SPN	U323
HGNC	19006
MGI	1314873
PubMed	16537918
RGD	1304941
UniProt	Q86Z02
Wiki	HIPK1

Homeodomain-interacting protein kinase 1 is an enzyme belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.

Northern blot analysis detected expression in all mouse and human tissues examined. RNA dot-blot analysis of human tissues detected expression in all adult and fetal tissues. Immunolocalization of Hipk1 in mouse fibroblasts detected punctate nuclear staining. Hipk1 also localized throughout the nucleus and was excluded only from nucleoli. In addition, there was a diffuse cytoplasmic staining.

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