Helicase Like Transcription Factor (HLTF)

HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1; Sucrose nonfermenting protein 2-like 3; RING finger protein 80; DNA-binding protein/plasminogen activator inhibitor 1 regulator

SPN	U320
HGNC	11099
MGI	1196437
PubMed	12901794
RGD	1309031
UniProt	Q14527
Wiki	HLTF

Helicase-like transcription factor is a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters.

Reference

"Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter."
J. Biol. Chem. 270:4575-4587(1995) [PubMed] [Europe PMC] [Abstract]

"Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene."
DNA Cell Biol. 15:429-442(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"On the regulation of the plasminogen activator inhibitor-1 gene expression."
Verh. K. Acad. Geneeskd. Belg. 55:225-264(1993) [PubMed] [Europe PMC] [Abstract]

"Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family."
Dev. Biol. 183:166-182(1997) [PubMed] [Europe PMC] [Abstract]

"Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene."
J. Biol. Chem. 274:19573-19580(1999) [PubMed] [Europe PMC] [Abstract]

"HLTF gene silencing in human colon cancer."
Proc. Natl. Acad. Sci. U.S.A. 99:4562-4567(2002) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination."
Proc. Natl. Acad. Sci. U.S.A. 105:3768-3773(2008) [PubMed] [Europe PMC] [Abstract]

"Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks."
Proc. Natl. Acad. Sci. U.S.A. 105:12411-12416(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Prolactin induces Jak2 phosphorylation of RUSHY195."
Mol. Cell. Endocrinol. 338:79-83(2011) [PubMed] [Europe PMC] [Abstract]

"NMR structure of the HLTF hiran domain."
Submitted (OCT-2010) to the PDB data bank