Intestinal Cell Kinase (ICK)

LCK2; MRK; Serine/threonine-protein kinase ICK; Laryngeal cancer kinase 2; MAK-related kinase

SPN	U310
HGNC	21219
MGI	1934157
PubMed	19696144
RGD	71050
UniProt	Q9UPZ9
Wiki	ICK_(gene

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. Serine/threonine-protein kinase ICK is an enzyme protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. ICK expression in all tissues examined, with highest expression in brain, spinal cord, testis, and ovary. Among specific brain regions, very high expression was detected in corpus callosum.

Reference

"Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases."
J. Cell. Physiol. 183:129-139(2000) [PubMed] [Europe PMC] [Abstract].

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport."
EMBO J. 33:1227-1242(2014) [PubMed] [Europe PMC] [Abstract]

"Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling."
Proc. Natl. Acad. Sci. U.S.A. 111:8541-8546(2014) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

"A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems."
Am. J. Hum. Genet. 84:134-147(2009) [PubMed] [Europe PMC] [Abstract]