Inosine Triphosphatase (ITPA)

ITPase; Nucleoside Triphosphate Pyrophosphatase; Inosine Triphosphate Pyrophosphatase; Non-canonical purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase

SPN	U302
HGNC	6176
MGI	96622
PubMed	17924837
RGD	1589751
UniProt	Q9BY32
Wiki	ITPA

Inosine triphosphate pyrophosphatase hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate.

The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.

Reference

"Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the ITPA gene."
J. Biol. Chem. 276:18695-18701(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]