Keratocan (KERA)
CNA2; SLRR2B; Keratocan Proteoglycan; Keratan sulfate proteoglycan keratocan
Keratocan is a protein encoded by the KERA gene.Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican, and mimecan , are important to the transparency of the cornea.
Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2). In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU296Hu01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU296Hu01 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| PAU296Hu01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU296Hu01 | CLIA Kit for Keratocan (KERA) | CLIA assay for Antigen Detection |
| ELU296Hu01 | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU296Mu01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU296Mu01 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| PAU296Mu01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU296Mu01 | CLIA Kit for Keratocan (KERA) | CLIA assay for Antigen Detection |
| ELU296Mu01 | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU296Ra01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU296Ra01 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| PAU296Ra01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU296Ra01 | CLIA Kit for Keratocan (KERA) | CLIA assay for Antigen Detection |
| ELU296Ra01 | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU296Ca01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU296Ca01 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| PAU296Ca01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU296Ca01 | CLIA Kit for Keratocan (KERA) | CLIA assay for Antigen Detection |
| ELU296Ca01 | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU296Po01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU296Po01 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| PAU296Po01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU296Po01 | CLIA Kit for Keratocan (KERA) | CLIA assay for Antigen Detection |
| ELU296Po01 | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU296Bo01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU296Bo01 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| PAU296Bo01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU296Bo01 | CLIA Kit for Keratocan (KERA) | CLIA assay for Antigen Detection |
| ELU296Bo01 | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU296Rb01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU296Rb01 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| PAU296Rb01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU296Rb01 | CLIA Kit for Keratocan (KERA) | CLIA assay for Antigen Detection |
| ELU296Rb01 | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU296Mo01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU296Mo01 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| PAU296Mo01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU296Mo01 | CLIA Kit for Keratocan (KERA) | CLIA assay for Antigen Detection |
| ELU296Mo01 | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Structure and sequence of the gene encoding human keratocan."
DNA Seq. 10:67-74(1999) [PubMed] [Europe PMC] [Abstract]
"Mutations in KERA, encoding keratocan, cause cornea plana."
Nat. Genet. 25:91-95(2000) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Keratocan expression is increased in the stroma of keratoconus corneas."
Mol. Med. 7:470-477(2001) [PubMed] [Europe PMC] [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
"A novel keratocan mutation causing autosomal recessive cornea plana."
Invest. Ophthalmol. Vis. Sci. 42:3118-3122(2001) [PubMed] [Europe PMC] [Abstract]