Lymphocyte Cytosolic Protein 1 (LCP1)

CP64; LC64P; PLS2; L-Plastin; Plastin 2

SPN	U288
HGNC	6528
MGI	104808
PubMed	10469447
RGD	1308288
UniProt	P13796
Wiki	LCP1

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.).

L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Reference

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"Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts."
Mol. Cell. Biol. 8:4659-4668(1988) [PubMed] [Europe PMC] [Abstract]

"Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain."
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, Submitted (MAY-2006) to UniProtKB

"Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells."
J. Biol. Chem. 268:2781-2792(1993) [PubMed] [Europe PMC] [Abstract]

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Biochemistry 29:1055-1062(1990) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1."
Biochemistry 27:3765-3770(1988) [PubMed] [Europe PMC] [Abstract]

"Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma."
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"Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells."
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"Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25."
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"Solution structure of the fourth CH domain from human L-plastin."
Submitted (JUN-2006) to the PDB data bank