Leukocyte Cell Derived Chemotaxin 1 (LECT1)
BRICD3; CHM-I; CHM1; CH-SP; Chondromodulin-1; Chondrosurfactant protein
LECT1 is a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. LECT1 expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU286Hu01 | Recombinant Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU286Hu01 | Monoclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IP. |
| PAU286Hu01 | Polyclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU286Hu01 | CLIA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | CLIA assay for Antigen Detection |
| ELU286Hu01 | ELISA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU286Mu01 | Recombinant Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU286Mu01 | Monoclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IP. |
| PAU286Mu01 | Polyclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU286Mu01 | CLIA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | CLIA assay for Antigen Detection |
| ELU286Mu01 | ELISA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU286Ra01 | Recombinant Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU286Ra01 | Monoclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IP. |
| PAU286Ra01 | Polyclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU286Ra01 | CLIA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | CLIA assay for Antigen Detection |
| ELU286Ra01 | ELISA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU286Ca01 | Recombinant Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU286Ca01 | Monoclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IP. |
| PAU286Ca01 | Polyclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU286Ca01 | CLIA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | CLIA assay for Antigen Detection |
| ELU286Ca01 | ELISA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU286Po01 | Recombinant Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU286Po01 | Monoclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IP. |
| PAU286Po01 | Polyclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU286Po01 | CLIA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | CLIA assay for Antigen Detection |
| ELU286Po01 | ELISA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU286Bo01 | Recombinant Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU286Bo01 | Monoclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IP. |
| PAU286Bo01 | Polyclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU286Bo01 | CLIA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | CLIA assay for Antigen Detection |
| ELU286Bo01 | ELISA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU286Rb01 | Recombinant Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU286Rb01 | Monoclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IP. |
| PAU286Rb01 | Polyclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU286Rb01 | CLIA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | CLIA assay for Antigen Detection |
| ELU286Rb01 | ELISA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU286Mo01 | Recombinant Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU286Mo01 | Monoclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IP. |
| PAU286Mo01 | Polyclonal Antibody to Leukocyte Cell Derived Chemotaxin 1 (LECT1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU286Mo01 | CLIA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | CLIA assay for Antigen Detection |
| ELU286Mo01 | ELISA Kit for Leukocyte Cell Derived Chemotaxin 1 (LECT1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Biochem. Biophys. Res. Commun. 249:885-890(1998) [PubMed] [Europe PMC] [Abstract]
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Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo."
FEBS Lett. 458:436-440(1999) [PubMed] [Europe PMC] [Abstract]
"Chondromodulin-I as a novel cartilage-specific growth-modulating factor."
Pediatr. Nephrol. 14:602-605(2000) [PubMed] [Europe PMC] [Abstract]
"Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis."
Nat. Med. 12:1151-1159(2006) [PubMed] [Europe PMC] [Abstract]