Eukaryotic translation initiation factor 2D (EIF2D)

HCA56; LGTN; Hepatocellular carcinoma-associated antigen 56; Ligatin

SPN	U284
HGNC	6583
MGI	109342
PubMed	3805022
RGD	1561765
UniProt	P41214

Ligatin is a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.Trafficking receptor for phosphoglycoproteins. Localizes phosphoglycoproteins within endosomes and at the cell periphery where they participate in specific metabolic processes as well as intercellular adhesion.

Reference

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"Molecular cloning of the cDNA for ligatin."
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Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

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