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Loricrin (LOR)

Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
There were multiple sequence variants within these 2 size class alleles due to various deletions of 12 bp (4 amino acids) in the major loop of this glycine loop domain. By use of a specific loricrin antibody in immunogold electron microscopy, they showed that loricrin appears initially in the granular layer of human epidermis and forms composite keratohyalin granules with profilaggrin, but localizes to the cell periphery (cell envelope) of fully differentiated stratum corneum cells.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU281Hu01 Recombinant Loricrin (LOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU281Hu01 Monoclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IP.
PAU281Hu01 Polyclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IF.
Assay Kits CLU281Hu01 CLIA Kit for Loricrin (LOR) CLIA assay for Antigen Detection
ELU281Hu01 ELISA Kit for Loricrin (LOR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU281Mu01 Recombinant Loricrin (LOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU281Mu01 Monoclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IP.
PAU281Mu01 Polyclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IF.
Assay Kits CLU281Mu01 CLIA Kit for Loricrin (LOR) CLIA assay for Antigen Detection
ELU281Mu01 ELISA Kit for Loricrin (LOR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU281Ra01 Recombinant Loricrin (LOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU281Ra01 Monoclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IP.
PAU281Ra01 Polyclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IF.
Assay Kits CLU281Ra01 CLIA Kit for Loricrin (LOR) CLIA assay for Antigen Detection
ELU281Ra01 ELISA Kit for Loricrin (LOR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU281Ca01 Recombinant Loricrin (LOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU281Ca01 Monoclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IP.
PAU281Ca01 Polyclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IF.
Assay Kits CLU281Ca01 CLIA Kit for Loricrin (LOR) CLIA assay for Antigen Detection
ELU281Ca01 ELISA Kit for Loricrin (LOR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU281Po01 Recombinant Loricrin (LOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU281Po01 Monoclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IP.
PAU281Po01 Polyclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IF.
Assay Kits CLU281Po01 CLIA Kit for Loricrin (LOR) CLIA assay for Antigen Detection
ELU281Po01 ELISA Kit for Loricrin (LOR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU281Bo01 Recombinant Loricrin (LOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU281Bo01 Monoclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IP.
PAU281Bo01 Polyclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IF.
Assay Kits CLU281Bo01 CLIA Kit for Loricrin (LOR) CLIA assay for Antigen Detection
ELU281Bo01 ELISA Kit for Loricrin (LOR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU281Rb01 Recombinant Loricrin (LOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU281Rb01 Monoclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IP.
PAU281Rb01 Polyclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IF.
Assay Kits CLU281Rb01 CLIA Kit for Loricrin (LOR) CLIA assay for Antigen Detection
ELU281Rb01 ELISA Kit for Loricrin (LOR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU281Mo01 Recombinant Loricrin (LOR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU281Mo01 Monoclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IP.
PAU281Mo01 Polyclonal Antibody to Loricrin (LOR) WB; IHC; ICC; IF.
Assay Kits CLU281Mo01 CLIA Kit for Loricrin (LOR) CLIA assay for Antigen Detection
ELU281Mo01 ELISA Kit for Loricrin (LOR) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins."
J. Biol. Chem. 266:6626-6636(1991) [PubMed] [Europe PMC] [Abstract]

"The human loricrin gene."
J. Biol. Chem. 267:18060-18066(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The molecular pathology of progressive symmetric erythrokeratoderma: a frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope."
Am. J. Hum. Genet. 61:581-589(1997) [PubMed] [Europe PMC] [Abstract]

"Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin."
J. Biol. Chem. 274:7226-7237(1999) [PubMed] [Europe PMC] [Abstract]

"A recurrent mutation in the loricrin gene underlies the ichthyotic variant of Vohwinkel syndrome."
Clin. Exp. Dermatol. 27:243-246(2002) [PubMed] [Europe PMC] [Abstract]

"Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin."
J. Dermatol. Sci. 31:3-8(2003) [PubMed] [Europe PMC] [Abstract]