Lysophospholipase I (LYPLA1)
APT1; LPL1; LYSOPLA; Acyl-Protein Thioesterase 1
Lysophospholipids (LysoPLs) are detergent-like intermediates in phospholipid metabolism. Increased LysoPL levels have been detected in a variety of diseases including atherosclerosis and hyperlipidemia. In some cases, increased levels of LysoPLs are hypothesized to result from a dysfunction of LysoPL-regulating enzymes including lysophospholipases, which act on biologic membranes to regulate the level of LysoPLs by hydrolysis.
Acyl-protein thioesterase 1 hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU274Hu01 | Recombinant Lysophospholipase I (LYPLA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU274Hu01 | Monoclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IP. |
| PAU274Hu01 | Polyclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU274Hu01 | CLIA Kit for Lysophospholipase I (LYPLA1) | CLIA assay for Antigen Detection |
| ELU274Hu01 | ELISA Kit for Lysophospholipase I (LYPLA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU274Mu01 | Recombinant Lysophospholipase I (LYPLA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU274Mu01 | Monoclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IP. |
| PAU274Mu01 | Polyclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU274Mu01 | CLIA Kit for Lysophospholipase I (LYPLA1) | CLIA assay for Antigen Detection |
| ELU274Mu01 | ELISA Kit for Lysophospholipase I (LYPLA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU274Ra01 | Recombinant Lysophospholipase I (LYPLA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU274Ra01 | Monoclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IP. |
| PAU274Ra01 | Polyclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU274Ra01 | CLIA Kit for Lysophospholipase I (LYPLA1) | CLIA assay for Antigen Detection |
| ELU274Ra01 | ELISA Kit for Lysophospholipase I (LYPLA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU274Ca01 | Recombinant Lysophospholipase I (LYPLA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU274Ca01 | Monoclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IP. |
| PAU274Ca01 | Polyclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU274Ca01 | CLIA Kit for Lysophospholipase I (LYPLA1) | CLIA assay for Antigen Detection |
| ELU274Ca01 | ELISA Kit for Lysophospholipase I (LYPLA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU274Po01 | Recombinant Lysophospholipase I (LYPLA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU274Po01 | Monoclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IP. |
| PAU274Po01 | Polyclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU274Po01 | CLIA Kit for Lysophospholipase I (LYPLA1) | CLIA assay for Antigen Detection |
| ELU274Po01 | ELISA Kit for Lysophospholipase I (LYPLA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU274Bo01 | Recombinant Lysophospholipase I (LYPLA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU274Bo01 | Monoclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IP. |
| PAU274Bo01 | Polyclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU274Bo01 | CLIA Kit for Lysophospholipase I (LYPLA1) | CLIA assay for Antigen Detection |
| ELU274Bo01 | ELISA Kit for Lysophospholipase I (LYPLA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU274Rb01 | Recombinant Lysophospholipase I (LYPLA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU274Rb01 | Monoclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IP. |
| PAU274Rb01 | Polyclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU274Rb01 | CLIA Kit for Lysophospholipase I (LYPLA1) | CLIA assay for Antigen Detection |
| ELU274Rb01 | ELISA Kit for Lysophospholipase I (LYPLA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU274Mo01 | Recombinant Lysophospholipase I (LYPLA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU274Mo01 | Monoclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IP. |
| PAU274Mo01 | Polyclonal Antibody to Lysophospholipase I (LYPLA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU274Mo01 | CLIA Kit for Lysophospholipase I (LYPLA1) | CLIA assay for Antigen Detection |
| ELU274Mo01 | ELISA Kit for Lysophospholipase I (LYPLA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A."
Structure 8:1137-1146(2000) [PubMed] [Europe PMC] [Abstract]
"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Small-molecule inhibition of APT1 affects Ras localization and signaling."
Nat. Chem. Biol. 6:449-456(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels."
J. Biol. Chem. 287:14718-14725(2012) [PubMed] [Europe PMC] [Abstract]