Luteinizing Hormone Beta Polypeptide (LHb)

LH-B; CGB4; LSH-B; hLHB; Lutropin Subunit Beta; Interstitial Cell Stimulating Hormone,Beta Chain

SPN	U271
HGNC	6584
MGI	96782
PubMed	2422163
RGD	3006
UniProt	P01229
Wiki	LHB

Lutropin subunit beta is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.

Reference

"Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone."
Nature 307:37-40(1984) [PubMed] [Europe PMC] [Abstract]

"Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit."
Biochim. Biophys. Acta 412:70-81(1975) [PubMed] [Europe PMC] [Abstract]

"The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH)."
J. Clin. Endocrinol. Metab. 36:618-621(1973) [PubMed] [Europe PMC] [Abstract]

"Structure and significance of human luteinizing hormone-beta core fragment purified from human pituitary extracts."
Endocrinology 133:985-989(1993) [PubMed] [Europe PMC] [Abstract]

"Human luteinizing hormone. The amino acid sequence of the subunit."
FEBS Lett. 29:97-100(1973) [PubMed] [Europe PMC] [Abstract]

"NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin."
Eur. J. Biochem. 195:257-268(1991) [PubMed] [Europe PMC] [Abstract]

"Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H]- and [15N]nuclear magnetic resonance spectroscopy."
Mol. Endocrinol. 6:904-913(1992) [PubMed] [Europe PMC] [Abstract]

"Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone."
N. Engl. J. Med. 326:179-183(1992) [PubMed] [Europe PMC] [Abstract]

"A new molecular variant of luteinizing hormone associated with female infertility."
Fertil. Steril. 69:102-106(1998) [PubMed] [Europe PMC] [Abstract]

"Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients."
Hum. Reprod. 13:3338-3344(1998) [PubMed] [Europe PMC] [Abstract]

"A novel Ala(-3)Thr mutation in the signal peptide of human luteinizing hormone beta-subunit: potentiation of the inositol phosphate signalling pathway and attenuation of the adenylate cyclase pathway by recombinant variant hormone."
Mol. Hum. Reprod. 8:201-212(2002) [PubMed] [Europe PMC] [Abstract]