Uncoupling Protein 2, Mitochondrial (UCP2)
SLC25A8; UCPH; Solute carrier family 25 member 8
UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H /OH- are not known. UCPs contain the three homologous protein domains of MACPs. Mitochondrial uncoupling protein 2 is expressed in many tissues, with the greatest expression in skeletal muscle. Although it was originally thought to play a role in nonshivering thermogenesis, obesity and diabetes, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species . Chromosomal order is 5'-UCP3-UCP2-3'.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU264Hu01 | Recombinant Uncoupling Protein 2, Mitochondrial (UCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU264Hu01 | Monoclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IP. |
| PAU264Hu01 | Polyclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU264Hu01 | CLIA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | CLIA assay for Antigen Detection |
| ELU264Hu01 | ELISA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU264Mu01 | Recombinant Uncoupling Protein 2, Mitochondrial (UCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU264Mu01 | Monoclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IP. |
| PAU264Mu01 | Polyclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU264Mu01 | CLIA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | CLIA assay for Antigen Detection |
| ELU264Mu01 | ELISA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU264Ra01 | Recombinant Uncoupling Protein 2, Mitochondrial (UCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU264Ra01 | Monoclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IP. |
| PAU264Ra01 | Polyclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU264Ra01 | CLIA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | CLIA assay for Antigen Detection |
| ELU264Ra01 | ELISA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU264Ca01 | Recombinant Uncoupling Protein 2, Mitochondrial (UCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU264Ca01 | Monoclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IP. |
| PAU264Ca01 | Polyclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU264Ca01 | CLIA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | CLIA assay for Antigen Detection |
| ELU264Ca01 | ELISA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU264Po01 | Recombinant Uncoupling Protein 2, Mitochondrial (UCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU264Po01 | Monoclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IP. |
| PAU264Po01 | Polyclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU264Po01 | CLIA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | CLIA assay for Antigen Detection |
| ELU264Po01 | ELISA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU264Bo01 | Recombinant Uncoupling Protein 2, Mitochondrial (UCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU264Bo01 | Monoclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IP. |
| PAU264Bo01 | Polyclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU264Bo01 | CLIA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | CLIA assay for Antigen Detection |
| ELU264Bo01 | ELISA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU264Rb01 | Recombinant Uncoupling Protein 2, Mitochondrial (UCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU264Rb01 | Monoclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IP. |
| PAU264Rb01 | Polyclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU264Rb01 | CLIA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | CLIA assay for Antigen Detection |
| ELU264Rb01 | ELISA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU264Mo01 | Recombinant Uncoupling Protein 2, Mitochondrial (UCP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU264Mo01 | Monoclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IP. |
| PAU264Mo01 | Polyclonal Antibody to Uncoupling Protein 2, Mitochondrial (UCP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU264Mo01 | CLIA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | CLIA assay for Antigen Detection |
| ELU264Mo01 | ELISA Kit for Uncoupling Protein 2, Mitochondrial (UCP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression."
FEBS Lett. 408:39-42(1997) [PubMed] [Europe PMC] [Abstract]
"Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia."
Nat. Genet. 15:269-272(1997) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis."
Diabetes 46:900-906(1997) [PubMed] [Europe PMC] [Abstract]
"Structure and organization of the human uncoupling protein 2 gene and identification of a common biallelic variant in Caucasian and African-American subjects."
Diabetes 47:685-687(1998) [PubMed] [Europe PMC] [Abstract]
"Functional organization of the human uncoupling protein-2 gene, and juxtaposition to the uncoupling protein-3 gene."
Biochem. Biophys. Res. Commun. 255:40-46(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans."
Nat. Genet. 28:178-183(2001) [PubMed] [Europe PMC] [Abstract]