Uroplakin 1A (UPK1A)

UPK1-A; TSPAN21; UP1A; UPIA; UPKA; Tetraspanin-21; Uroplakin Ia

SPN	U262
HGNC	12577
MGI	98911
PubMed	20978196
RGD	1309849
UniProt	O00322
Wiki	UPK1A

Uroplakin-1a is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU262Hu01	Recombinant Uroplakin 1A (UPK1A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU262Hu01	Monoclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IP.
Antibodies	PAU262Hu01	Polyclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IF.
Assay Kits	CLU262Hu01	CLIA Kit for Uroplakin 1A (UPK1A)	CLIA assay for Antigen Detection
Assay Kits	ELU262Hu01	ELISA Kit for Uroplakin 1A (UPK1A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU262Mu01	Recombinant Uroplakin 1A (UPK1A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU262Mu01	Monoclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IP.
Antibodies	PAU262Mu01	Polyclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IF.
Assay Kits	CLU262Mu01	CLIA Kit for Uroplakin 1A (UPK1A)	CLIA assay for Antigen Detection
Assay Kits	ELU262Mu01	ELISA Kit for Uroplakin 1A (UPK1A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU262Ra01	Recombinant Uroplakin 1A (UPK1A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU262Ra01	Monoclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IP.
Antibodies	PAU262Ra01	Polyclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IF.
Assay Kits	CLU262Ra01	CLIA Kit for Uroplakin 1A (UPK1A)	CLIA assay for Antigen Detection
Assay Kits	ELU262Ra01	ELISA Kit for Uroplakin 1A (UPK1A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU262Ca01	Recombinant Uroplakin 1A (UPK1A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU262Ca01	Monoclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IP.
Antibodies	PAU262Ca01	Polyclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IF.
Assay Kits	CLU262Ca01	CLIA Kit for Uroplakin 1A (UPK1A)	CLIA assay for Antigen Detection
Assay Kits	ELU262Ca01	ELISA Kit for Uroplakin 1A (UPK1A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU262Po01	Recombinant Uroplakin 1A (UPK1A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU262Po01	Monoclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IP.
Antibodies	PAU262Po01	Polyclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IF.
Assay Kits	CLU262Po01	CLIA Kit for Uroplakin 1A (UPK1A)	CLIA assay for Antigen Detection
Assay Kits	ELU262Po01	ELISA Kit for Uroplakin 1A (UPK1A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU262Bo01	Recombinant Uroplakin 1A (UPK1A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU262Bo01	Monoclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IP.
Antibodies	PAU262Bo01	Polyclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IF.
Assay Kits	CLU262Bo01	CLIA Kit for Uroplakin 1A (UPK1A)	CLIA assay for Antigen Detection
Assay Kits	ELU262Bo01	ELISA Kit for Uroplakin 1A (UPK1A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU262Rb01	Recombinant Uroplakin 1A (UPK1A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU262Rb01	Monoclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IP.
Antibodies	PAU262Rb01	Polyclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IF.
Assay Kits	CLU262Rb01	CLIA Kit for Uroplakin 1A (UPK1A)	CLIA assay for Antigen Detection
Assay Kits	ELU262Rb01	ELISA Kit for Uroplakin 1A (UPK1A)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU262Mo01	Recombinant Uroplakin 1A (UPK1A)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU262Mo01	Monoclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IP.
Antibodies	PAU262Mo01	Polyclonal Antibody to Uroplakin 1A (UPK1A)	WB; IHC; ICC; IF.
Assay Kits	CLU262Mo01	CLIA Kit for Uroplakin 1A (UPK1A)	CLIA assay for Antigen Detection
Assay Kits	ELU262Mo01	ELISA Kit for Uroplakin 1A (UPK1A)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Transcriptional control of the human urothelial-specific gene, uroplakin Ia."
Biochim. Biophys. Acta 1729:126-134(2005) [PubMed] [Europe PMC] [Abstract]

"Uroplakin gene expression by normal and neoplastic human urothelium."
Am. J. Pathol. 153:1957-1967(1998) [PubMed] [Europe PMC] [Abstract]