Ubiquitously Expressed Transcript (UXT)

ART27; Androgen receptor trapped clone 27 protein; Ubiquitously expressed transcript protein

SPN	U258
HGNC	12641
MGI	1277988
PubMed	24021647
RGD	1359326
UniProt	Q9UBK9
Wiki	UXT

Protein UXT is a novel protein which is highly conserved in mouse. It interacts with the N-terminus of the androgen receptor and plays a role in facilitating receptor-induced transcriptional activation. It is also likely to be involved in tumorigenesis as it is abundantly expressed in tumor tissues. This gene is part of a gene cluster on chromosome Xp11.23. Alternative splicing results in 2 transcript variants encoding different isoforms.

Based on a consensus sequence from 14 different ESTs with significant sequence similarity to UXT, they determined that UXT encodes a 157-amino acid protein with 3 potential phosphorylation sites. a protein that shares 90% identity with human UXT, with all 3 potential phosphorylation sites conserved, indicating that these sites are of functional importance.

Reference

"Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue."
Genomics 56:340-343(1999) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus."
Mol. Biol. Cell 13:670-682(2002) [PubMed] [Europe PMC] [Abstract]

"UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation."
FEBS J. 274:3960-3971(2007) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity."
Genomics 79:124-136(2002) [PubMed] [Europe PMC] [Abstract]

"UXT is a novel centrosomal protein essential for cell viability."
Mol. Biol. Cell 16:5857-5865(2005) [PubMed] [Europe PMC] [Abstract]

"UXT (Ubiquitously Expressed Transcript) causes mitochondrial aggregation."
In Vitro Cell. Dev. Biol. Anim. 43:139-146(2007) [PubMed] [Europe PMC] [Abstract]

"UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome."
J. Cell Biol. 178:231-244(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP."
Mol. Cell. Biol. 31:3639-3652(2011) [PubMed] [Europe PMC] [Abstract]