Uridine Monophosphate Synthetase (UMPS)

OPRT; Orotate Phosphoribosyl Transferase; Orotidine-5'-Decarboxylase; Orotate phosphoribosyltransferase; Orotidine 5'-phosphate decarboxylase

SPN	U257
HGNC	12563
MGI	1298388
PubMed	8069469
RGD	1311908
UniProt	P11172
Wiki	UMPS

Uridine monophosphate synthetase (UMPS) is the enzyme (EC 4.1.1.23) that catalyses the formation of uridine monophosphate (UMP), an energy carrying molecule in many important biosynthetic pathways. In humans, the gene that codes for this enzyme is located on the long arm of chromosome 3 (3q13).Deficiency of this enzyme is an inherited autosomal recessive trait in Holstein cattle, and it will cause death before birth.Deficiency of the enzyme can be studied in the model organism Caenorhabditis elegans. The rad-6 strain has a premature stop codon eliminating the orotidine 5’-decarboxylase domain of the protein; this domain does not occur in any other proteins encoded by the genome. The strain has a pleiotropic phenotype including reduced viability and fertility, slow growth and radiation sensitivity.

Reference

"Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase."
Proc. Natl. Acad. Sci. U.S.A. 85:1754-1758(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of human UMP synthase."
Adv. Exp. Med. Biol. 253A:511-518(1989) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families."
Am. J. Hum. Genet. 60:525-539(1997) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular genetic studies on hereditary orotic aciduria: I. Purification of human orotidine 5'-monophosphate decarboxylase and cloning of its cDNA."
Nagoya Med. J. 32:207-220(1988)

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design."
Structure 16:82-92(2008) [PubMed] [Europe PMC] [Abstract]