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Vanin 1 (VNN1)

Pantetheinase; Pantetheine hydrolase; Tiff66; Vascular non-inflammatory molecule 1

Pantetheinase is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU253Hu01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU253Hu01 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAU253Hu01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IF.
Assay Kits CLU253Hu01 CLIA Kit for Vanin 1 (VNN1) CLIA assay for Antigen Detection
ELU253Hu01 ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU253Mu01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU253Mu01 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAU253Mu01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IF.
Assay Kits CLU253Mu01 CLIA Kit for Vanin 1 (VNN1) CLIA assay for Antigen Detection
ELU253Mu01 ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU253Ra01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU253Ra01 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAU253Ra01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IF.
Assay Kits CLU253Ra01 CLIA Kit for Vanin 1 (VNN1) CLIA assay for Antigen Detection
ELU253Ra01 ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU253Ca01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU253Ca01 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAU253Ca01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IF.
Assay Kits CLU253Ca01 CLIA Kit for Vanin 1 (VNN1) CLIA assay for Antigen Detection
ELU253Ca01 ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU253Po01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU253Po01 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAU253Po01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IF.
Assay Kits CLU253Po01 CLIA Kit for Vanin 1 (VNN1) CLIA assay for Antigen Detection
ELU253Po01 ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU253Bo01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU253Bo01 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAU253Bo01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IF.
Assay Kits CLU253Bo01 CLIA Kit for Vanin 1 (VNN1) CLIA assay for Antigen Detection
ELU253Bo01 ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU253Rb01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU253Rb01 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAU253Rb01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IF.
Assay Kits CLU253Rb01 CLIA Kit for Vanin 1 (VNN1) CLIA assay for Antigen Detection
ELU253Rb01 ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU253Mo01 Recombinant Vanin 1 (VNN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU253Mo01 Monoclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IP.
PAU253Mo01 Polyclonal Antibody to Vanin 1 (VNN1) WB; IHC; ICC; IF.
Assay Kits CLU253Mo01 CLIA Kit for Vanin 1 (VNN1) CLIA assay for Antigen Detection
ELU253Mo01 ELISA Kit for Vanin 1 (VNN1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6."
Genomics 53:203-213(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Is pantetheinase the actual identity of mouse and human vanin-1 proteins?"
FEBS Lett. 461:149-152(1999) [PubMed] [Europe PMC] [Abstract]

"Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes."
Immunogenetics 53:296-306(2001) [PubMed] [Europe PMC] [Abstract]

"A proteomic analysis of human bile."
Mol. Cell. Proteomics 3:715-728(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines."
J. Invest. Dermatol. 129:2167-2174(2009) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]