Vascular Endothelial Growth Inhibitor (VEGI)

TNFSF15; TL1; TL1A; VEGI192A; Tumor Necrosis Factor(ligand)Superfamily,Member 15; TNF Superfamily Ligand TL1A; TNF Ligand-Related Molecule 1

SPN	U249
HGNC	11931
MGI	2180140
PubMed	24023314
RGD	628735
UniProt	O95150
Wiki	TNFSF15

VEGI is an anti-angiogenic protein. It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. The protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.

Reference

"VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo."
FASEB J. 13:181-189(1999) [PubMed] [Europe PMC] [Abstract]

"A novel secreted splice variant of vascular endothelial cell growth inhibitor."
FASEB J. 16:742-744(2002) [PubMed] [Europe PMC] [Abstract]

"TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator."
Immunity 16:479-492(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells."
Gene 204:35-46(1997) [PubMed] [Europe PMC] [Abstract]

"VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth."
Oncogene 18:6496-6504(1999) [PubMed] [Europe PMC] [Abstract]

"X-ray crystal structure of TNF ligand family member TL1A at 2.1A."
Biochem. Biophys. Res. Commun. 364:1-6(2007) [PubMed] [Europe PMC] [Abstract]

"Decoy strategies: the structure of TL1A:DcR3 complex."
Structure 19:162-171(2011) [PubMed] [Europe PMC] [Abstract]