Inhibitor Of Apoptosis Protein, X-Linked (XIAP)

BIRC4; API3; ILP1; MIHA; XLP2; Baculoviral IAP Repeat-Containing 4; E3 ubiquitin-protein ligase XIAP; IAP-like; Inhibitor of apoptosis protein 3; X-linked inhibitor of apoptosis protein

SPN	U245
HGNC	592
MGI	107572
PubMed	21402697
RGD	620692
UniProt	P98170
Wiki	XIAP

X-linked Inhibitor of Apoptosis Protein (XIAP) is a member of the Inhibitor of apoptosis family of proteins (IAP). IAPs were initially identified in baculoviruses, but XIAP is one of the homologous proteins found in mammals. It is so called because it was first discovered by a 273 base pair site on the X chromosome.The protein is also called human IAP-like Protein (hILP), because it is not as well conserved as the human IAPS: hIAP-1 and hIAP-2. XIAP is the most potent human IAP protein currently identified.XIAP, like the rest of the IAP family, has two major structural elements. Firstly, there is the baculoviral IAP repeat (BIR) domain consisting of approximately 70 amino acids. Secondly, there is a zinc-binding domain, or a “carboxy-terminal RING Finger”.

Reference

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EMBO J. 15:2685-2694(1996) [PubMed] [Europe PMC] [Abstract]

"Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes."
Nature 379:349-353(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"X-linked IAP is a direct inhibitor of cell-death proteases."
Nature 388:300-304(1997) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death."
Proc. Natl. Acad. Sci. U.S.A. 98:8662-8667(2001) [PubMed] [Europe PMC] [Abstract]

"HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins."
J. Biol. Chem. 277:445-454(2002) [PubMed] [Europe PMC] [Abstract]

"Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro."
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"Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein."
Biochem. J. 373:965-971(2003) [PubMed] [Europe PMC] [Abstract]

"A novel role for XIAP in copper homeostasis through regulation of MURR1."
EMBO J. 23:244-254(2004) [PubMed] [Europe PMC] [Abstract]

"The mitochondrial ARTS protein promotes apoptosis through targeting XIAP."
EMBO J. 23:1627-1635(2004) [PubMed] [Europe PMC] [Abstract]

"Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)."
J. Biol. Chem. 279:5405-5412(2004) [PubMed] [Europe PMC] [Abstract]

"cIAP1 Localizes to the nuclear compartment and modulates the cell cycle."
Cancer Res. 65:210-218(2005) [PubMed] [Europe PMC] [Abstract]

"XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome."
Nature 444:110-114(2006) [PubMed] [Europe PMC] [Abstract]

"XIAP: cell death regulation meets copper homeostasis."
Arch. Biochem. Biophys. 463:168-174(2007) [PubMed] [Europe PMC] [Abstract]

"Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein."
Biochem. Biophys. Res. Commun. 366:432-437(2008) [PubMed] [Europe PMC] [Abstract]

"IAPs: more than just inhibitors of apoptosis proteins."
Cell Cycle 7:1036-1046(2008) [PubMed] [Europe PMC] [Abstract]

"Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP."
Mol. Cell. Biol. 28:237-247(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization."
J. Biol. Chem. 284:20462-20466(2009) [PubMed] [Europe PMC] [Abstract]

"Molecular interaction between HAX-1 and XIAP inhibits apoptosis."
Biochem. Biophys. Res. Commun. 393:794-799(2010) [PubMed] [Europe PMC] [Abstract]

"To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death."
Curr. Opin. Cell Biol. 22:872-881(2010) [PubMed] [Europe PMC] [Abstract]

"Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death."
Mol. Cell 39:184-195(2010) [PubMed] [Europe PMC] [Abstract]

"Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases."
Mol. Cell 40:810-822(2010) [PubMed] [Europe PMC] [Abstract]

"Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination."
Mol. Cell. Biol. 30:1923-1936(2010) [PubMed] [Europe PMC] [Abstract]

"IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer."
Nat. Rev. Cancer 10:561-574(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation."
Biochemistry 50:11084-11096(2011) [PubMed] [Europe PMC] [Abstract]

"Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity."
Discov. Med. 11:221-231(2011) [PubMed] [Europe PMC] [Abstract]

"Survivin monomer plays an essential role in apoptosis regulation."
J. Biol. Chem. 286:23296-23307(2011) [PubMed] [Europe PMC] [Abstract]

"The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2."
J. Biol. Chem. 286:35380-35387(2011) [PubMed] [Europe PMC] [Abstract]

"cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)."
PLoS ONE 6:E22356-E22356(2011) [PubMed] [Europe PMC] [Abstract]

"IAPs: guardians of RIPK1."
Cell Death Differ. 19:58-66(2012) [PubMed] [Europe PMC] [Abstract]

"XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."
Mol. Cell 45:619-628(2012) [PubMed] [Europe PMC] [Abstract]

"NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP."
Nature 401:818-822(1999) [PubMed] [Europe PMC] [Abstract]

"Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain."
Nature 408:1004-1008(2000) [PubMed] [Europe PMC] [Abstract]

"Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain."
Cell 104:781-790(2001) [PubMed] [Europe PMC] [Abstract]

"Mechanism of XIAP-mediated inhibition of caspase-9."
Mol. Cell 11:519-527(2003) [PubMed] [Europe PMC] [Abstract]

"Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer."
J. Med. Chem. 47:4417-4426(2004) [PubMed] [Europe PMC] [Abstract]

"Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP."
Bioorg. Med. Chem. 15:2935-2943(2007) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the BIR1 domain of XIAP in two crystal forms."
J. Mol. Biol. 372:847-854(2007) [PubMed] [Europe PMC] [Abstract]

"XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization."
Mol. Cell 26:689-702(2007) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the RING domain of the baculoviral IAP repeat-containing protein 4 from Homo sapiens."
Submitted (MAR-2008) to the PDB data bank