Call Now

Mitofusin 1 (MFN1)

Hfzo1; Hfzo2; Transmembrane GTPase MFN1; Fzo homolog

Mitofusin-1 is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.
The deduced 741-amino acid protein contains an N-terminal GTPase domain and a transmembrane domain near the C terminus. MFN1 shares 60% identity with MFN2, with the most extensive homology in the GTPase domains. The N- and C-terminal ends are more variable. When stably expressed in COS-7 cells, MFN1 colocalized with mitochondrial markers. Overexpression of MFN1 caused perinuclear mitochondrial clustering.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU232Hu01 Recombinant Mitofusin 1 (MFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU232Hu01 Monoclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IP.
PAU232Hu01 Polyclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IF.
Assay Kits CLU232Hu01 CLIA Kit for Mitofusin 1 (MFN1) CLIA assay for Antigen Detection
ELU232Hu01 ELISA Kit for Mitofusin 1 (MFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU232Mu01 Recombinant Mitofusin 1 (MFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU232Mu01 Monoclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IP.
PAU232Mu01 Polyclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IF.
Assay Kits CLU232Mu01 CLIA Kit for Mitofusin 1 (MFN1) CLIA assay for Antigen Detection
ELU232Mu01 ELISA Kit for Mitofusin 1 (MFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU232Ra01 Recombinant Mitofusin 1 (MFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU232Ra01 Monoclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IP.
PAU232Ra01 Polyclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IF.
Assay Kits CLU232Ra01 CLIA Kit for Mitofusin 1 (MFN1) CLIA assay for Antigen Detection
ELU232Ra01 ELISA Kit for Mitofusin 1 (MFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU232Ca01 Recombinant Mitofusin 1 (MFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU232Ca01 Monoclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IP.
PAU232Ca01 Polyclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IF.
Assay Kits CLU232Ca01 CLIA Kit for Mitofusin 1 (MFN1) CLIA assay for Antigen Detection
ELU232Ca01 ELISA Kit for Mitofusin 1 (MFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU232Po01 Recombinant Mitofusin 1 (MFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU232Po01 Monoclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IP.
PAU232Po01 Polyclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IF.
Assay Kits CLU232Po01 CLIA Kit for Mitofusin 1 (MFN1) CLIA assay for Antigen Detection
ELU232Po01 ELISA Kit for Mitofusin 1 (MFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU232Bo01 Recombinant Mitofusin 1 (MFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU232Bo01 Monoclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IP.
PAU232Bo01 Polyclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IF.
Assay Kits CLU232Bo01 CLIA Kit for Mitofusin 1 (MFN1) CLIA assay for Antigen Detection
ELU232Bo01 ELISA Kit for Mitofusin 1 (MFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU232Rb01 Recombinant Mitofusin 1 (MFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU232Rb01 Monoclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IP.
PAU232Rb01 Polyclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IF.
Assay Kits CLU232Rb01 CLIA Kit for Mitofusin 1 (MFN1) CLIA assay for Antigen Detection
ELU232Rb01 ELISA Kit for Mitofusin 1 (MFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU232Mo01 Recombinant Mitofusin 1 (MFN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU232Mo01 Monoclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IP.
PAU232Mo01 Polyclonal Antibody to Mitofusin 1 (MFN1) WB; IHC; ICC; IF.
Assay Kits CLU232Mo01 CLIA Kit for Mitofusin 1 (MFN1) CLIA assay for Antigen Detection
ELU232Mo01 ELISA Kit for Mitofusin 1 (MFN1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Control of mitochondrial morphology by a human mitofusin."
J. Cell Sci. 114:867-874(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase."
Cell 90:121-129(1997) [PubMed] [Europe PMC] [Abstract]

"Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display."
Cancer Res. 61:8873-8879(2001) [PubMed] [Europe PMC] [Abstract]

"Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo."
J. Cell Sci. 115:1663-1674(2002) [PubMed] [Europe PMC] [Abstract]

"Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins."
Mol. Biol. Cell 13:4343-4354(2002) [PubMed] [Europe PMC] [Abstract]

"Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells."
J. Cell Sci. 116:2763-2774(2003) [PubMed] [Europe PMC] [Abstract]

"Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1."
J. Cell Sci. 123:619-626(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission."
J. Biol. Chem. 288:27584-27593(2013) [PubMed] [Europe PMC] [Abstract]

"The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy."
Nat. Neurosci. 16:1257-1265(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]