Methionine Sulfoxide Reductase A (MSRA)
PMSR; Peptide Methionine Sulfoxide Reductase; Protein-methionine-S-oxide reductase
Peptide methionine sulfoxide reductase is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. MSRA mRNA is highly expressed in rat and human kidney, but to a lesser extent in other rat tissues. The highest specific activity of the mammalian MSRA enzyme was found in cell-free extracts prepared from rat kidney and human neutrophils. Neutrophils and macrophages are known to produce reactive oxygen species during a respiratory burst that kill invading bacteria during phagocytosis. It is suggested that MSRA functions to repair oxidative damage to proteins that may occur during oxidative bursts or other situations where reactive oxygen radicals exist.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU222Hu01 | Recombinant Methionine Sulfoxide Reductase A (MSRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU222Hu01 | Monoclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IP. |
| PAU222Hu01 | Polyclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU222Hu01 | CLIA Kit for Methionine Sulfoxide Reductase A (MSRA) | CLIA assay for Antigen Detection |
| ELU222Hu01 | ELISA Kit for Methionine Sulfoxide Reductase A (MSRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU222Mu01 | Recombinant Methionine Sulfoxide Reductase A (MSRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU222Mu01 | Monoclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IP. |
| PAU222Mu01 | Polyclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU222Mu01 | CLIA Kit for Methionine Sulfoxide Reductase A (MSRA) | CLIA assay for Antigen Detection |
| ELU222Mu01 | ELISA Kit for Methionine Sulfoxide Reductase A (MSRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU222Ra01 | Recombinant Methionine Sulfoxide Reductase A (MSRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU222Ra01 | Monoclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IP. |
| PAU222Ra01 | Polyclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU222Ra01 | CLIA Kit for Methionine Sulfoxide Reductase A (MSRA) | CLIA assay for Antigen Detection |
| ELU222Ra01 | ELISA Kit for Methionine Sulfoxide Reductase A (MSRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU222Ca01 | Recombinant Methionine Sulfoxide Reductase A (MSRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU222Ca01 | Monoclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IP. |
| PAU222Ca01 | Polyclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU222Ca01 | CLIA Kit for Methionine Sulfoxide Reductase A (MSRA) | CLIA assay for Antigen Detection |
| ELU222Ca01 | ELISA Kit for Methionine Sulfoxide Reductase A (MSRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU222Po01 | Recombinant Methionine Sulfoxide Reductase A (MSRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU222Po01 | Monoclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IP. |
| PAU222Po01 | Polyclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU222Po01 | CLIA Kit for Methionine Sulfoxide Reductase A (MSRA) | CLIA assay for Antigen Detection |
| ELU222Po01 | ELISA Kit for Methionine Sulfoxide Reductase A (MSRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU222Bo01 | Recombinant Methionine Sulfoxide Reductase A (MSRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU222Bo01 | Monoclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IP. |
| PAU222Bo01 | Polyclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU222Bo01 | CLIA Kit for Methionine Sulfoxide Reductase A (MSRA) | CLIA assay for Antigen Detection |
| ELU222Bo01 | ELISA Kit for Methionine Sulfoxide Reductase A (MSRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU222Rb01 | Recombinant Methionine Sulfoxide Reductase A (MSRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU222Rb01 | Monoclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IP. |
| PAU222Rb01 | Polyclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU222Rb01 | CLIA Kit for Methionine Sulfoxide Reductase A (MSRA) | CLIA assay for Antigen Detection |
| ELU222Rb01 | ELISA Kit for Methionine Sulfoxide Reductase A (MSRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU222Mo01 | Recombinant Methionine Sulfoxide Reductase A (MSRA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU222Mo01 | Monoclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IP. |
| PAU222Mo01 | Polyclonal Antibody to Methionine Sulfoxide Reductase A (MSRA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU222Mo01 | CLIA Kit for Methionine Sulfoxide Reductase A (MSRA) | CLIA assay for Antigen Detection |
| ELU222Mo01 | ELISA Kit for Methionine Sulfoxide Reductase A (MSRA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA)."
FEBS Lett. 456:17-21(1999) [PubMed] [Europe PMC] [Abstract]
"Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation."
Biochim. Biophys. Acta 1703:239-247(2005) [PubMed] [Europe PMC] [Abstract]
"Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina."
Exp. Eye Res. 82:816-827(2006) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins."
FASEB J. 16:911-913(2002) [PubMed] [Europe PMC] [Abstract]
"Dual sites of protein initiation control the localization and myristoylation of methionine sulfoxide reductase A."
J. Biol. Chem. 285:18085-18094(2010) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]