Myelin Transcription Factor 1 (MYT1)

MTF1; MYTI; PLPB1; Proteolipid protein-binding protein

SPN	U214
HGNC	7622
MGI	1100535
PubMed	7569953
RGD	1304899
UniProt	Q01538
Wiki	MYT1

Myelin transcription factor 1 is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.

Reference

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"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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"Novel member of the zinc finger superfamily: a C2-HC finger that recognizes a glia-specific gene."
Mol. Cell. Biol. 12:5632-5639(1992) [PubMed] [Europe PMC] [Abstract]

"Expression of myelin transcription factor I (MyTI), a 'zinc-finger' DNA-binding protein, in developing oligodendrocytes."
Glia 14:303-321(1995) [PubMed] [Europe PMC] [Abstract]

"The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase."
Proc. Natl. Acad. Sci. U.S.A. 100:2284-2289(2003) [PubMed] [Europe PMC] [Abstract]

"Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells."
Mol. Cell. Neurosci. 25:111-123(2004) [PubMed] [Europe PMC] [Abstract]