Neuro Oncological Ventral Antigen 1 (NOVA1)
Onconeural ventral antigen 1; Paraneoplastic Ri antigen; Ventral neuron-specific protein 1; RNA-binding protein Nova-1
RNA-binding protein Nova-1 is a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.
Autoantigen in the paraneoplastic opsoclonus myoclonus ataxia (POMA), a paraneoplastic neurological syndrome/disorder (PNS/D) associated with breast cancer, fallopian cancer, and SCLCa and characterized primarily by loss of inhibitory control of motor neurons in the spinal cord and brainstem. Recognized by the IgG autoantibody ANNA-2
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU190Hu01 | Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU190Hu01 | Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IP. |
| PAU190Hu01 | Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU190Hu01 | CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | CLIA assay for Antigen Detection |
| ELU190Hu01 | ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU190Mu01 | Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU190Mu01 | Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IP. |
| PAU190Mu01 | Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU190Mu01 | CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | CLIA assay for Antigen Detection |
| ELU190Mu01 | ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU190Ra01 | Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU190Ra01 | Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IP. |
| PAU190Ra01 | Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU190Ra01 | CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | CLIA assay for Antigen Detection |
| ELU190Ra01 | ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU190Ca01 | Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU190Ca01 | Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IP. |
| PAU190Ca01 | Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU190Ca01 | CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | CLIA assay for Antigen Detection |
| ELU190Ca01 | ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU190Po01 | Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU190Po01 | Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IP. |
| PAU190Po01 | Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU190Po01 | CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | CLIA assay for Antigen Detection |
| ELU190Po01 | ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU190Bo01 | Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU190Bo01 | Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IP. |
| PAU190Bo01 | Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU190Bo01 | CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | CLIA assay for Antigen Detection |
| ELU190Bo01 | ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU190Rb01 | Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU190Rb01 | Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IP. |
| PAU190Rb01 | Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU190Rb01 | CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | CLIA assay for Antigen Detection |
| ELU190Rb01 | ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU190Mo01 | Recombinant Neuro Oncological Ventral Antigen 1 (NOVA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU190Mo01 | Monoclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IP. |
| PAU190Mo01 | Polyclonal Antibody to Neuro Oncological Ventral Antigen 1 (NOVA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU190Mo01 | CLIA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | CLIA assay for Antigen Detection |
| ELU190Mo01 | ELISA Kit for Neuro Oncological Ventral Antigen 1 (NOVA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system."
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Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains."
Structure 7:191-203(1999) [PubMed] [Europe PMC] [Abstract]