Neuronal Cell Adhesion Molecule (NRCAM)

Bravo; NgCAM-Related Cell Adhesion Molecule; Neuronal surface protein Bravo

SPN	U184
HGNC	7994
MGI	104750
PubMed	16123759
RGD	3209
UniProt	Q92823
Wiki	NRCAM

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. Neuronal cell adhesion molecule is a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

Reference

"Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31."
Genomics 35:456-465(1996) [PubMed] [Europe PMC] [Abstract]

"The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily."
Gene 273:115-122(2001) [PubMed] [Europe PMC] [Abstract]

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J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the first fibronectin type III domain of human KIAA0343 protein."
Submitted (NOV-2003) to the PDB data bank

"Solution structure of the third fibronectin III domain of human KIAA0343 protein."
Submitted (NOV-2003) to the PDB data bank

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]