Ornithine Decarboxylase Antizyme 1 (OAZ1)
AZI; OAZ; ODC-Az
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting.
Ornithine decarboxylase antizyme inhibits ornithine decarboxylase and accelerates its degradation.Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU168Hu01 | Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU168Hu01 | Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IP. |
| PAU168Hu01 | Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU168Hu01 | CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | CLIA assay for Antigen Detection |
| ELU168Hu01 | ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU168Mu01 | Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU168Mu01 | Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IP. |
| PAU168Mu01 | Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU168Mu01 | CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | CLIA assay for Antigen Detection |
| ELU168Mu01 | ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU168Ra01 | Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU168Ra01 | Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IP. |
| PAU168Ra01 | Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU168Ra01 | CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | CLIA assay for Antigen Detection |
| ELU168Ra01 | ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU168Ca01 | Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU168Ca01 | Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IP. |
| PAU168Ca01 | Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU168Ca01 | CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | CLIA assay for Antigen Detection |
| ELU168Ca01 | ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU168Po01 | Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU168Po01 | Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IP. |
| PAU168Po01 | Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU168Po01 | CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | CLIA assay for Antigen Detection |
| ELU168Po01 | ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU168Bo01 | Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU168Bo01 | Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IP. |
| PAU168Bo01 | Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU168Bo01 | CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | CLIA assay for Antigen Detection |
| ELU168Bo01 | ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU168Rb01 | Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU168Rb01 | Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IP. |
| PAU168Rb01 | Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU168Rb01 | CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | CLIA assay for Antigen Detection |
| ELU168Rb01 | ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU168Mo01 | Recombinant Ornithine Decarboxylase Antizyme 1 (OAZ1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU168Mo01 | Monoclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IP. |
| PAU168Mo01 | Polyclonal Antibody to Ornithine Decarboxylase Antizyme 1 (OAZ1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU168Mo01 | CLIA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | CLIA assay for Antigen Detection |
| ELU168Mo01 | ELISA Kit for Ornithine Decarboxylase Antizyme 1 (OAZ1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme."
Biochim. Biophys. Acta 1209:293-295(1994) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of human antizyme cDNA."
Biochem. Mol. Biol. Int. 38:957-964(1996) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human antizyme gene."
Gene 203:131-139(1997) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)."
BMC Cell Biol. 3:15-15(2002) [PubMed] [Europe PMC] [Abstract]
"Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase."
Biochem. J. 409:187-192(2008) [PubMed] [Europe PMC] [Abstract]