Oxysterol Binding Protein (OSBP)

OSBP1

SPN	U159
HGNC	8503
MGI	97447
PubMed	11238399
RGD	1308069
UniProt	P22059
Wiki	OSBP

Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase.

Oxysterol-binding proteins are evolutionary related proteins involved with sterol synthesis and/or its regulation. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds a variety of oxysterols (oxygenated derivatives of cholesterol); yeast OSH1, a protein of 859 residues that also plays a role in ergosterol synthesis; and yeast proteins HES1 and KES1, highly related proteins of 434 residues that seem to play a role in ergosterol synthesis

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU159Hu01	Recombinant Oxysterol Binding Protein (OSBP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU159Hu01	Monoclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IP.
Antibodies	PAU159Hu01	Polyclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IF.
Assay Kits	CLU159Hu01	CLIA Kit for Oxysterol Binding Protein (OSBP)	CLIA assay for Antigen Detection
Assay Kits	ELU159Hu01	ELISA Kit for Oxysterol Binding Protein (OSBP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU159Mu01	Recombinant Oxysterol Binding Protein (OSBP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU159Mu01	Monoclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IP.
Antibodies	PAU159Mu01	Polyclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IF.
Assay Kits	CLU159Mu01	CLIA Kit for Oxysterol Binding Protein (OSBP)	CLIA assay for Antigen Detection
Assay Kits	ELU159Mu01	ELISA Kit for Oxysterol Binding Protein (OSBP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU159Ra01	Recombinant Oxysterol Binding Protein (OSBP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU159Ra01	Monoclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IP.
Antibodies	PAU159Ra01	Polyclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IF.
Assay Kits	CLU159Ra01	CLIA Kit for Oxysterol Binding Protein (OSBP)	CLIA assay for Antigen Detection
Assay Kits	ELU159Ra01	ELISA Kit for Oxysterol Binding Protein (OSBP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU159Ca01	Recombinant Oxysterol Binding Protein (OSBP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU159Ca01	Monoclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IP.
Antibodies	PAU159Ca01	Polyclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IF.
Assay Kits	CLU159Ca01	CLIA Kit for Oxysterol Binding Protein (OSBP)	CLIA assay for Antigen Detection
Assay Kits	ELU159Ca01	ELISA Kit for Oxysterol Binding Protein (OSBP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU159Po01	Recombinant Oxysterol Binding Protein (OSBP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU159Po01	Monoclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IP.
Antibodies	PAU159Po01	Polyclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IF.
Assay Kits	CLU159Po01	CLIA Kit for Oxysterol Binding Protein (OSBP)	CLIA assay for Antigen Detection
Assay Kits	ELU159Po01	ELISA Kit for Oxysterol Binding Protein (OSBP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU159Bo01	Recombinant Oxysterol Binding Protein (OSBP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU159Bo01	Monoclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IP.
Antibodies	PAU159Bo01	Polyclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IF.
Assay Kits	CLU159Bo01	CLIA Kit for Oxysterol Binding Protein (OSBP)	CLIA assay for Antigen Detection
Assay Kits	ELU159Bo01	ELISA Kit for Oxysterol Binding Protein (OSBP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU159Rb01	Recombinant Oxysterol Binding Protein (OSBP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU159Rb01	Monoclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IP.
Antibodies	PAU159Rb01	Polyclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IF.
Assay Kits	CLU159Rb01	CLIA Kit for Oxysterol Binding Protein (OSBP)	CLIA assay for Antigen Detection
Assay Kits	ELU159Rb01	ELISA Kit for Oxysterol Binding Protein (OSBP)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPU159Mo01	Recombinant Oxysterol Binding Protein (OSBP)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAU159Mo01	Monoclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IP.
Antibodies	PAU159Mo01	Polyclonal Antibody to Oxysterol Binding Protein (OSBP)	WB; IHC; ICC; IF.
Assay Kits	CLU159Mo01	CLIA Kit for Oxysterol Binding Protein (OSBP)	CLIA assay for Antigen Detection
Assay Kits	ELU159Mo01	ELISA Kit for Oxysterol Binding Protein (OSBP)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19."
Genomics 7:65-74(1990) [PubMed] [Europe PMC] [Abstract]

"Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina."
J. Biol. Chem. 276:18570-18578(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation."
Science 307:1472-1476(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"OSBP negatively regulates ABCA1 protein stability."
J. Biol. Chem. 283:18210-18217(2008) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies."
J. Biol. Chem. 285:12961-12970(2010) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]