Oxoguanine Glycosylase 1 (OGG1)

HMMH; HOGG1; MUTM; OGH1; 8-Oxoguanine DNA Glycosylase; DNA-(apurinic or apyrimidinic site) lyase; N-glycosylase/DNA lyase

SPN	U150
HGNC	8125
MGI	1097693
PubMed	16614128
RGD	621168
UniProt	O15527
Wiki	OGG1

OGG1 is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen species (ROS). The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targeting signal, essential for mitochondrial localization.

Reference

"Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue."
Cancer Res. 57:2151-2156(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase."
Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase."
Proc. Natl. Acad. Sci. U.S.A. 94:8016-8020(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae."
Proc. Natl. Acad. Sci. U.S.A. 94:8010-8015(1997) [PubMed] [Europe PMC] [Abstract]

"A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer."
Curr. Biol. 7:397-407(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage."
Oncogene 14:2857-2861(1997) [PubMed] [Europe PMC] [Abstract]

"Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers."
J. Exp. Med. 186:1547-1556(1997) [PubMed] [Europe PMC] [Abstract]

"Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites."
EMBO J. 16:6314-6322(1997) [PubMed] [Europe PMC] [Abstract]

"Structure and chromosome location of human OGG1."
Cytogenet. Cell Genet. 85:232-236(1999) [PubMed] [Europe PMC] [Abstract]

"Expression and differential intracellular localization of two major forms of human 8-Oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs."
Mol. Biol. Cell 10:1637-1652(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis."
Arch. Biochem. Biophys. 377:1-8(2000) [PubMed] [Europe PMC] [Abstract]

"UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles."
J. Cell Sci. 120:23-32(2007) [PubMed] [Europe PMC] [Abstract]

"Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA."
Nature 403:859-866(2000) [PubMed] [Europe PMC] [Abstract]

"Reciprocal 'flipping'; underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase."
J. Mol. Biol. 317:171-177(2002) [PubMed] [Europe PMC] [Abstract]

"Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase."
Biochemistry 42:1564-1572(2003) [PubMed] [Europe PMC] [Abstract]

"Product-assisted catalysis in base-excision DNA repair."
Nat. Struct. Biol. 10:204-211(2003) [PubMed] [Europe PMC] [Abstract]

"Structures of end products resulting from lesion processing by a DNA glycosylase/lyase."
Chem. Biol. 11:1643-1649(2004) [PubMed] [Europe PMC] [Abstract]

"Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations."
J. Biol. Chem. 282:9182-9194(2007) [PubMed] [Europe PMC] [Abstract]

"Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer."
Jpn. J. Cancer Res. 89:825-828(1998) [PubMed] [Europe PMC] [Abstract]

"Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours."
Oncogene 16:3083-3086(1998) [PubMed] [Europe PMC] [Abstract]

"Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations."
Nucleic Acids Res. 27:4001-4007(1999) [PubMed] [Europe PMC] [Abstract]

"Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the ogg1 protein."
Nucleic Acids Res. 28:2672-2678(2000) [PubMed] [Europe PMC] [Abstract]

"Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer."
DNA Repair 1:497-505(2002) [PubMed] [Europe PMC] [Abstract]