Pericentrin (PCNT)

KEN; PCN; PCNT2; PCNTB; PCTN2; SCKL4; Kendrin; Seckel Syndrome 4; Pericentrin-B

SPN	U140
HGNC	16068
MGI	102722
PubMed	8124707
UniProt	O95613
Wiki	PCNT

Pericentrin (kendrin), also known as PCNT, is a protein binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM).

The protein contains a series of coiled coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component γ-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell cycle progression.Expressed in all tissues tested, including placenta, liver, kidney and thymus. pericentrin is a conserved integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays.

Reference

"Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1."
J. Cell Sci. 114:797-809(2001) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 21."
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin."
Proc. Natl. Acad. Sci. U.S.A. 97:5919-5923(2000) [PubMed] [Europe PMC] [Abstract]

"DISC1-kendrin interaction is involved in centrosomal microtubule network formation."
Biochem. Biophys. Res. Commun. 377:1051-1056(2008) [PubMed] [Europe PMC] [Abstract]

"Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling."
Nat. Genet. 40:232-236(2008) [PubMed] [Europe PMC] [Abstract]

"Mutations in the pericentrin (PCNT) gene cause primordial dwarfism."
Science 319:816-819(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity."
Biochem. Biophys. Res. Commun. 398:217-223(2010) [PubMed] [Europe PMC] [Abstract]

"Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex."
J. Biol. Chem. 285:22658-22665(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The centriolar satellite protein Cep131 is important for genome stability."
J. Cell Sci. 125:4770-4779(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Diagnostic exome sequencing in persons with severe intellectual disability."
N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]

"Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability."
J. Cell Sci. 127:2910-2919(2014) [PubMed] [Europe PMC] [Abstract]