Call Now

Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1)

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

PDK1codes for an isozyme of pyruvate dehydrogenase kinase (PDK).The human PDK1 gene encodes a protein with a predicted molecular mass of 49,244 Da that shares 93% identity with that of the rat PDK1 gene. Northern blot analysis showed that the PDK1 message was expressed predominantly in the heart.
Pyruvate dehydrogenase (PDH) is a part of a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU139Hu01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU139Hu01 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
PAU139Hu01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IF.
Assay Kits CLU139Hu01 CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA assay for Antigen Detection
ELU139Hu01 ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU139Mu01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU139Mu01 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
PAU139Mu01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IF.
Assay Kits CLU139Mu01 CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA assay for Antigen Detection
ELU139Mu01 ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU139Ra01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU139Ra01 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
PAU139Ra01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IF.
Assay Kits CLU139Ra01 CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA assay for Antigen Detection
ELU139Ra01 ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU139Ca01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU139Ca01 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
PAU139Ca01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IF.
Assay Kits CLU139Ca01 CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA assay for Antigen Detection
ELU139Ca01 ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU139Po01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU139Po01 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
PAU139Po01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IF.
Assay Kits CLU139Po01 CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA assay for Antigen Detection
ELU139Po01 ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU139Bo01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU139Bo01 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
PAU139Bo01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IF.
Assay Kits CLU139Bo01 CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA assay for Antigen Detection
ELU139Bo01 ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU139Rb01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU139Rb01 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
PAU139Rb01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IF.
Assay Kits CLU139Rb01 CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA assay for Antigen Detection
ELU139Rb01 ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU139Mo01 Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU139Mo01 Monoclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IP.
PAU139Mo01 Polyclonal Antibody to Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) WB; IHC; ICC; IF.
Assay Kits CLU139Mo01 CLIA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) CLIA assay for Antigen Detection
ELU139Mo01 ELISA Kit for Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Diversity of the pyruvate dehydrogenase kinase gene family in humans."
J. Biol. Chem. 270:28989-28994(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells."
J. Biol. Chem. 283:22700-22708(2008) [PubMed] [Europe PMC] [Abstract]

"Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer."
Am. J. Pathol. 179:1405-1414(2011) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism."
Mol. Cell 44:864-877(2011) [PubMed] [Europe PMC] [Abstract]

"Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol."
Structure 15:992-1004(2007) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]